ID A0A1H4LKC2_9MICC Unreviewed; 859 AA.
AC A0A1H4LKC2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=SAMN04489745_1036 {ECO:0000313|EMBL:SEB71117.1};
OS Arthrobacter woluwensis.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Arthrobacter.
OX NCBI_TaxID=156980 {ECO:0000313|EMBL:SEB71117.1, ECO:0000313|Proteomes:UP000182652};
RN [1] {ECO:0000313|EMBL:SEB71117.1, ECO:0000313|Proteomes:UP000182652}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 10495 {ECO:0000313|EMBL:SEB71117.1,
RC ECO:0000313|Proteomes:UP000182652};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; FNSN01000003; SEB71117.1; -; Genomic_DNA.
DR RefSeq; WP_066211849.1; NZ_FNSN01000003.1.
DR AlphaFoldDB; A0A1H4LKC2; -.
DR STRING; 156980.SAMN04489745_1036; -.
DR Proteomes; UP000182652; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd01987; USP_OKCHK; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 1.20.120.620; Backbone structure of the membrane domain of e. Coli histidine kinase receptor kdpd; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR038318; KdpD_sf.
DR InterPro; IPR025201; KdpD_TM.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR003852; Sig_transdc_His_kinase_KdpD_N.
DR InterPro; IPR006016; UspA.
DR PANTHER; PTHR45569; SENSOR PROTEIN KDPD; 1.
DR PANTHER; PTHR45569:SF1; SENSOR PROTEIN KDPD; 1.
DR Pfam; PF13493; DUF4118; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF02702; KdpD; 1.
DR Pfam; PF00582; Usp; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:SEB71117.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000182652};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 379..398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 404..423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 456..477
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 623..840
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 859 AA; 91319 MW; 61B1405AC5221193 CRC64;
MRRGRLRVFL GAAPGVGKTY AMLEEAHRLR ASGEDVVVAV ALDHGRPQTA RLLDGLETVP
LRRHTHRGAA LEEMDLDAVL ERAPAVAVVD EYAHSNAPGC RNAKRWEDVE ELLAAGIDVL
STVNVQHLAS LHDVVQAITG TRQQETIPDA VVRHADQIEL VDIAPELLRQ RLSQGDVYPA
ENIDAALANY FRLGNLSALR EIALIWLADR VDEGLARYRE HQGIEGTWPA RERIVVGLTG
GPEGEVLLRR AARILSRVND GDLLAVHVRR ADGLDDGSAG RLGAQQRLVE DLGGRFVHVS
GEDVAASLLD YARGANATQI VIGVSRHGRL HQLLGTGVSN AVVRGSGDID VHLVTHPFTG
RQAALPSAAP SLSRLRTTLG FVLAVVGPPL ITLLLSPFQG LDLATHVLAH LCVVIAVAFV
GGLKPAVPAA ILDSLLLNFF VTPPVDTFTI SDPQNLFALI VFLGVAIAVS LVVGLSARRS
VEARRARAEA VTLSELASSS LASDQSPAEF LRQVRQEFSL ESVSLFERDG SQAAGDDAGW
RLSASSGAGA PGSPAEAGTA EELSPTALLA WNGRVLSGGE RRLLRAFESH LLALLERDRL
ALSLADTVKL AEGNRIRTSL LQAASHDLRT PLAGIGLAAT ALRRQRGKMT EEEEEEMLET
IESCNHRLES LIANLLDMSR ISGDAVTVLH EPVSWLEVVP EALSGVSEGE VRVELAPNLP
PVDADRGLLE RALANLVENA VKHAPDSGVV LVATPGGLLG PVLDGRPASE LRVVDHGSGV
AQERLAEMFQ PFRQLDTQAS GLGLGLAVAR GFIEAMGGEL TAEPTPGGGL TMVVRLPLYA
GPHSHGTALG SREGQEEQA
//
