ID   A0A1H4MSE8_9RHOB        Unreviewed;       443 AA.
AC   A0A1H4MSE8;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=Zinc metalloprotease {ECO:0000256|RuleBase:RU362031};
DE            EC=3.4.24.- {ECO:0000256|RuleBase:RU362031};
GN   ORFNames=SAMN05519105_1458 {ECO:0000313|EMBL:SEB85919.1};
OS   Rhodobacter sp. 24-YEA-8.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Paracoccaceae; Rhodobacter.
OX   NCBI_TaxID=1884310 {ECO:0000313|EMBL:SEB85919.1, ECO:0000313|Proteomes:UP000199640};
RN   [1] {ECO:0000313|EMBL:SEB85919.1, ECO:0000313|Proteomes:UP000199640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=24-YEA-8 {ECO:0000313|EMBL:SEB85919.1,
RC   ECO:0000313|Proteomes:UP000199640};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|RuleBase:RU362031};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the peptidase M50B family.
CC       {ECO:0000256|ARBA:ARBA00007931, ECO:0000256|RuleBase:RU362031}.
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DR   EMBL; FNSK01000001; SEB85919.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H4MSE8; -.
DR   STRING; 1884310.SAMN05519105_1458; -.
DR   OrthoDB; 9782003at2; -.
DR   Proteomes; UP000199640; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00989; PDZ_metalloprotease; 1.
DR   CDD; cd06163; S2P-M50_PDZ_RseP-like; 1.
DR   Gene3D; 2.30.42.10; -; 2.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR041489; PDZ_6.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR004387; Pept_M50_Zn.
DR   InterPro; IPR008915; Peptidase_M50.
DR   NCBIfam; TIGR00054; RIP metalloprotease RseP; 1.
DR   PANTHER; PTHR42837:SF2; MEMBRANE METALLOPROTEASE ARASP2, CHLOROPLASTIC-RELATED; 1.
DR   PANTHER; PTHR42837; REGULATOR OF SIGMA-E PROTEASE RSEP; 1.
DR   Pfam; PF17820; PDZ_6; 1.
DR   Pfam; PF02163; Peptidase_M50; 1.
DR   SMART; SM00228; PDZ; 2.
DR   SUPFAM; SSF50156; PDZ domain-like; 2.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU362031};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362031};
KW   Metal-binding {ECO:0000256|RuleBase:RU362031};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW   ECO:0000256|RuleBase:RU362031};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:SEB85919.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199640};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362031};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362031};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU362031}.
FT   TRANSMEM        6..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362031"
FT   TRANSMEM        109..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362031"
FT   TRANSMEM        337..358
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362031"
FT   TRANSMEM        370..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362031"
FT   TRANSMEM        416..437
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362031"
FT   DOMAIN          133..200
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|SMART:SM00228"
FT   DOMAIN          202..269
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|SMART:SM00228"
SQ   SEQUENCE   443 AA;  46835 MW;  BE0DCEBB245DC0AD CRC64;
     MDILGLLTGA AWSVVFFIVA LSIIVAIHEY GHYIIGRWSG IHAEVFSLGF GPVLLSRVDK
     RGTRWQVAAI PFGGYVKFLG DADAASVRSE VPSGLSASER RHTMAGAPLW ARASTVLAGP
     VANFILTFAI LLGTVLFNGI ALDRPIVGKL VPVPGVQTLQ EGDVILALGG RATPDNKSFG
     EAMRALPRDA EVEFRVERDG QELTLMAPHP QPGLMGGVQV KSAAIDAGLQ AGDVVVRADG
     KDINAFEDLA DIVRGSNGRT LPLTVWRDGR TFDLELTPRS RDVPRAAADG GGFETRWLLG
     AFSGMTFEPA SRPAGVWEAV TTAASAMWNM TTTTFSGLWH MIVGQISTCN MSGVIGMAET
     MGDAAKTGTM GFLSMLAVLS LGVGILNLLP IPVLDGGHLV FHAFEAVTGK PPSDGALRVL
     MTVGLTLLLS LMAFALWNDV TCV
//