ID   A0A1H4NQZ8_9ACTN        Unreviewed;       586 AA.
AC   A0A1H4NQZ8;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=FADH2 O2-dependent halogenase {ECO:0000313|EMBL:SEB97539.1};
GN   ORFNames=SAMN05216482_1641 {ECO:0000313|EMBL:SEB97539.1};
OS   Streptomyces sp. PAN_FS17.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1855351 {ECO:0000313|EMBL:SEB97539.1, ECO:0000313|Proteomes:UP000199275};
RN   [1] {ECO:0000313|Proteomes:UP000199275}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PAN_FS17 {ECO:0000313|Proteomes:UP000199275};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the flavin-dependent halogenase family.
CC       Bacterial tryptophan halogenase subfamily.
CC       {ECO:0000256|ARBA:ARBA00038396}.
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DR   EMBL; FNTN01000001; SEB97539.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H4NQZ8; -.
DR   STRING; 1855351.SAMN05216482_1641; -.
DR   OrthoDB; 103324at2; -.
DR   Proteomes; UP000199275; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006905; Flavin_halogenase.
DR   PANTHER; PTHR43747:SF1; FAD-BINDING DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR   Pfam; PF04820; Trp_halogenase; 2.
DR   PRINTS; PR00420; RNGMNOXGNASE.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199275};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   586 AA;  66244 MW;  9C5536941273DDB9 CRC64;
     MQDDQRVFDV AIVGGGIGGT MLAAILARHG VRVLLLEGSG HPRFAIGEST VPETTFGLRV
     LARRYDVPEI EHLATNGALR RHVSSNCGVK RNFSFVYHRE GEPTRAEECT QYPTWGPPLG
     PDSHYLRQDV DAYMFHVAVS YGATAHTHTV VDDVKFDEDG VTLVTREKGT FQASYVVDAG
     GMRALLPERL GLRQEPPYRT RSRTIFTHMV NVRPFDTVAP PREQHRMPSP FSQGTLHHLF
     QGGWFWVIPF DNHSAGTSQL CSVGINLDLD RHPRPEGVSA EEEFWRHVRK FPSVARQFEG
     ARAVRPYVST DRTQFSSRSV VGGRWCLLPH ASDFIDPLFS SGLAVTVMAL NALSHRIIDA
     VREDDFDTAR FGYLEQWIKR MFRFYDDLVS CSYVSFDDFE LWNAWNRVWT ITTLYGTNAQ
     NQAAVAFEKT GDPASFTALE TAPYRGLQGV DNPWVGQLFE QARDVVLAYG SGDLTKDQAV
     TRIFDLLRES GLCPAVWGTL DPQDRCPSGV FTLWPLMRIL LWGRFRSPQH VRGTYFTGGA
     RLVGKEAVQA LTTDVRRGSS LVQQTVRDMW VNWNRDWTRR EIPSRK
//