ID A0A1H4NT31_9MICO Unreviewed; 332 AA.
AC A0A1H4NT31;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=23S rRNA (Guanosine2251-2'-O)-methyltransferase {ECO:0000313|EMBL:SEB97802.1};
GN ORFNames=SAMN04489806_2280 {ECO:0000313|EMBL:SEB97802.1};
OS Microbacterium humi.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Microbacterium.
OX NCBI_TaxID=640635 {ECO:0000313|EMBL:SEB97802.1, ECO:0000313|Proteomes:UP000199183};
RN [1] {ECO:0000313|EMBL:SEB97802.1, ECO:0000313|Proteomes:UP000199183}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21799 {ECO:0000313|EMBL:SEB97802.1,
RC ECO:0000313|Proteomes:UP000199183};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class IV-like SAM-binding methyltransferase
CC superfamily. RNA methyltransferase TrmH family.
CC {ECO:0000256|ARBA:ARBA00007228}.
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DR EMBL; FNRY01000001; SEB97802.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H4NT31; -.
DR STRING; 640635.SAMN04489806_2280; -.
DR OrthoDB; 9785673at2; -.
DR Proteomes; UP000199183; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd18103; SpoU-like_RlmB; 1.
DR Gene3D; 3.30.1330.30; -; 1.
DR Gene3D; 3.40.1280.10; -; 1.
DR InterPro; IPR029028; Alpha/beta_knot_MTases.
DR InterPro; IPR029064; Ribosomal_eL30-like_sf.
DR InterPro; IPR004441; rRNA_MeTrfase_TrmH.
DR InterPro; IPR001537; SpoU_MeTrfase.
DR InterPro; IPR013123; SpoU_subst-bd.
DR InterPro; IPR029026; tRNA_m1G_MTases_N.
DR NCBIfam; TIGR00186; rRNA_methyl_3; 1.
DR PANTHER; PTHR46429; 23S RRNA (GUANOSINE-2'-O-)-METHYLTRANSFERASE RLMB; 1.
DR PANTHER; PTHR46429:SF1; 23S RRNA (GUANOSINE-2'-O-)-METHYLTRANSFERASE RLMB; 1.
DR Pfam; PF00588; SpoU_methylase; 1.
DR Pfam; PF08032; SpoU_sub_bind; 1.
DR SMART; SM00967; SpoU_sub_bind; 1.
DR SUPFAM; SSF75217; alpha/beta knot; 1.
DR SUPFAM; SSF55315; L30e-like; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000313|EMBL:SEB97802.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000199183};
KW Transferase {ECO:0000313|EMBL:SEB97802.1}.
FT DOMAIN 87..164
FT /note="RNA 2-O ribose methyltransferase substrate binding"
FT /evidence="ECO:0000259|SMART:SM00967"
FT REGION 1..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..62
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 332 AA; 34814 MW; C2E181ADC6471355 CRC64;
MASSKGRPGA MKKNKKGPQK GTGGLGRKAL EGKGPTPKAE DRTYHPAGKR KAARERLEAA
RGGRPQSKQS PGGRPPVKRS KNDDTEIVTG RNSVLEALRA RIPATSLYVA TRIEMDDRVK
EILSMATGRG IPVLEVTRPE LDRMGGFDSV HQGVAIAVPP YEYAHPVDLL EKAVDSGRTP
LLVALDGVTD PRNLGAIIRS TAAFGGQGVI VPQRRSAGVT AAAWKTSAGA AARTPVAMAA
NLTQSLKELK KQGVFVIGLD GGGDTSLHEL ELADRPIVVV VGSEGKGLSR LVTETCDAIV
SIPISAATES LNAGIAASVT LYEIAKRRAE QG
//
