GenomeNet

Database: UniProt
Entry: A0A1H4PHE1_9MICC
LinkDB: A0A1H4PHE1_9MICC
Original site: A0A1H4PHE1_9MICC 
ID   A0A1H4PHE1_9MICC        Unreviewed;       906 AA.
AC   A0A1H4PHE1;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   RecName: Full=DNA polymerase I {ECO:0000256|RuleBase:RU004460};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU004460};
GN   Name=polA {ECO:0000256|RuleBase:RU004460};
GN   ORFNames=SAMN04489745_1967 {ECO:0000313|EMBL:SEC06492.1};
OS   Arthrobacter woluwensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC   Arthrobacter.
OX   NCBI_TaxID=156980 {ECO:0000313|EMBL:SEC06492.1, ECO:0000313|Proteomes:UP000182652};
RN   [1] {ECO:0000313|EMBL:SEC06492.1, ECO:0000313|Proteomes:UP000182652}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 10495 {ECO:0000313|EMBL:SEC06492.1,
RC   ECO:0000313|Proteomes:UP000182652};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: In addition to polymerase activity, this DNA polymerase
CC       exhibits 5'-3' exonuclease activity. {ECO:0000256|RuleBase:RU004460}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632,
CC         ECO:0000256|RuleBase:RU004460};
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC       {ECO:0000256|ARBA:ARBA00007705, ECO:0000256|RuleBase:RU004460}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FNSN01000003; SEC06492.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H4PHE1; -.
DR   STRING; 156980.SAMN04489745_1967; -.
DR   Proteomes; UP000182652; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:UniProt.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd08637; DNA_pol_A_pol_I_C; 1.
DR   CDD; cd06140; DNA_polA_I_Bacillus_like_exo; 1.
DR   CDD; cd09898; H3TH_53EXO; 1.
DR   CDD; cd09859; PIN_53EXO; 1.
DR   Gene3D; 3.30.70.370; -; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 2.
DR   Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N.
DR   InterPro; IPR002421; 5-3_exonuclease.
DR   InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR   InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR020045; DNA_polI_H3TH.
DR   InterPro; IPR018320; DNA_polymerase_1.
DR   InterPro; IPR002298; DNA_polymerase_A.
DR   InterPro; IPR008918; HhH2.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   NCBIfam; TIGR00593; pola; 1.
DR   PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR   PANTHER; PTHR10133:SF27; DNA POLYMERASE NU; 1.
DR   Pfam; PF01367; 5_3_exonuc; 1.
DR   Pfam; PF02739; 5_3_exonuc_N; 1.
DR   Pfam; PF00476; DNA_pol_A; 1.
DR   PRINTS; PR00868; DNAPOLI.
DR   SMART; SM00475; 53EXOc; 1.
DR   SMART; SM00279; HhH2; 1.
DR   SMART; SM00482; POLAc; 1.
DR   SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF88723; PIN domain-like; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|RuleBase:RU004460};
KW   DNA repair {ECO:0000256|RuleBase:RU004460};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW   ECO:0000256|RuleBase:RU004460};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004460};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW   ECO:0000256|RuleBase:RU004460};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW   ECO:0000256|RuleBase:RU004460};
KW   Reference proteome {ECO:0000313|Proteomes:UP000182652};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004460}.
FT   DOMAIN          13..274
FT                   /note="5'-3' exonuclease"
FT                   /evidence="ECO:0000259|SMART:SM00475"
FT   DOMAIN          662..869
FT                   /note="DNA-directed DNA polymerase family A palm"
FT                   /evidence="ECO:0000259|SMART:SM00482"
SQ   SEQUENCE   906 AA;  98902 MW;  4D923472F5656A61 CRC64;
     MAPSDQASPG TRNRLLVLDG HSMAFRAFFA LPADNFATST GQHTNAVHGF TSMLINLIKD
     QQPTHVAVAF DVSDDTTFRK KEYDGYKGGR NATPEEFRGQ IDLIDQVMGA WGIKTLRMPG
     YEADDILATL AAQGEEAGWE VLLVSGDRDA FQLITDNVFV LYPKKGVSDI PRMDADAVRE
     KYFVGPEQYS DLAALVGETA DNLPGVPGVG PKTAAKWINL YGGLPGILEN LDSIGGKVGD
     ALRAHIEDVK RNRRLNRLLT DLDLGVALDE LAAPRPDQDA VEELFDALEF RTLRTRLFAL
     YGEDTEGVQH EGVELPPFEI GADAESLTTF LAGDTGGVPA ALAVASVAGG IGQEASAVAI
     LRGESARYLD LTELDAATEG VLAAWLADSG QEKAIHEYKE AFKALQARGL TLEGVVDDTS
     ISGYLIQPDR RNYELAELVQ HHLKITLESA PAVPAGQLDL GLDVDGTAAQ ARAEALVREA
     AAVRALSDHL APLLVERQAD QLLLTLELPV ARVLADMEIT GISVSREKMQ EQLDDLARQV
     EIAQQGAYAA IGHEVNLGSP KQLQTVLFEE LALPKTKKIK SGYTTDAASL KNLLEKTGHE
     FLVQLMAHRE ASKLRQMVET LYKSVAEDGR IHTTYAQNVA ATGRISSNNP NLQNIPVRSE
     EGRRVRDLFE VSEGYECLLA ADYSQIEMRI MAHLSEDAGL IQAYRDGEDL HRYVGSHIFG
     VAPEDVTSAM RSKVKAMSYG LAYGLTSFGL SKQLEISVDE ARTLMKDYFD RFGAVRDYLR
     GVVEQARQDG YTATIEGRRR YLPDLTSTDR HLREIAERVA LNSPIQGSAA DIIKRAMLGV
     ARALQEEGLK SRLLLQVHDE LVLEVAQGER EQVEQLVIRE MGNAAELSVP LDVQVGEGHS
     WHDAGH
//
DBGET integrated database retrieval system