ID   A0A1H4R5J1_9ACTN        Unreviewed;       336 AA.
AC   A0A1H4R5J1;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE            EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN   ORFNames=SAMN05216489_00313 {ECO:0000313|EMBL:SEC27162.1};
OS   Streptomyces sp. 3213.3.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1855348 {ECO:0000313|EMBL:SEC27162.1, ECO:0000313|Proteomes:UP000198754};
RN   [1] {ECO:0000313|EMBL:SEC27162.1, ECO:0000313|Proteomes:UP000198754}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3213 {ECO:0000313|EMBL:SEC27162.1,
RC   ECO:0000313|Proteomes:UP000198754};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC         methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC         ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00001709};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FNTK01000001; SEC27162.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H4R5J1; -.
DR   STRING; 1855348.SAMN05216489_00313; -.
DR   Proteomes; UP000198754; Unassembled WGS sequence.
DR   GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:InterPro.
DR   CDD; cd06558; crotonase-like; 1.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR045004; ECH_dom.
DR   InterPro; IPR032259; HIBYL-CoA-H.
DR   PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR   Pfam; PF16113; ECH_2; 1.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198754}.
FT   DOMAIN          17..329
FT                   /note="Enoyl-CoA hydratase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF16113"
SQ   SEQUENCE   336 AA;  35566 MW;  0F85027A47A4B445 CRC64;
     MPDTAAVEIL ADVHRGVGRI VLNRPRALNA LTTGMVAAID RVLAAWEDTP LSAVLIASAS
     TKAFCAGGDI RTIREHSLAG DAEASERFFA SEYRLNARIA EYSVPVVSLI DGLCMGGGLG
     LSVHGAFRVV TERAVLAMPE TGIGFFPDIG ASYFLPRLPG AIGMYLGLTG HRLDAADALY
     TGLATHFVPA DLLDTAADAL ADSPDEPVDV VLNRLAGRSP VAESGLAAVR GEVDWAFGAP
     TLGEIDKRLR HLDTPWAAAA LGALESASPQ SLEITHALLA RGRQRTLREC LEAELALTRT
     TIRTPDFLEG VRAALVDKDR TPTWQRASLG GRTLPS
//