ID A0A1H4S4X3_9FLAO Unreviewed; 721 AA.
AC A0A1H4S4X3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE RecName: Full=prolyl oligopeptidase {ECO:0000256|ARBA:ARBA00011897};
DE EC=3.4.21.26 {ECO:0000256|ARBA:ARBA00011897};
GN ORFNames=SAMN04489761_2862 {ECO:0000313|EMBL:SEC39088.1};
OS Tenacibaculum sp. MAR_2009_124.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Tenacibaculum.
OX NCBI_TaxID=1250059 {ECO:0000313|EMBL:SEC39088.1, ECO:0000313|Proteomes:UP000199366};
RN [1] {ECO:0000313|EMBL:SEC39088.1, ECO:0000313|Proteomes:UP000199366}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mar_2009_124 {ECO:0000313|EMBL:SEC39088.1,
RC ECO:0000313|Proteomes:UP000199366};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.;
CC EC=3.4.21.26; Evidence={ECO:0000256|ARBA:ARBA00001070};
CC -!- SIMILARITY: Belongs to the peptidase S9A family.
CC {ECO:0000256|ARBA:ARBA00005228}.
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DR EMBL; FNSF01000005; SEC39088.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H4S4X3; -.
DR STRING; 1250059.SAMN04489761_2862; -.
DR OrthoDB; 9801421at2; -.
DR Proteomes; UP000199366; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.130.10.120; Prolyl oligopeptidase, N-terminal domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002471; Pept_S9_AS.
DR InterPro; IPR023302; Pept_S9A_N.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002470; Peptidase_S9A.
DR PANTHER; PTHR42881; PROLYL ENDOPEPTIDASE; 1.
DR PANTHER; PTHR42881:SF2; PROLYL ENDOPEPTIDASE; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR Pfam; PF02897; Peptidase_S9_N; 1.
DR PRINTS; PR00862; PROLIGOPTASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF50993; Peptidase/esterase 'gauge' domain; 1.
DR PROSITE; PS00708; PRO_ENDOPEP_SER; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000199366}.
FT DOMAIN 35..433
FT /note="Peptidase S9A N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02897"
FT DOMAIN 493..706
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
SQ SEQUENCE 721 AA; 80557 MW; A25ED3182B03FE4C CRC64;
MKKIIFPVLA ASFILVSCEK PVNKITKRDI AVTYPATDKK PIVDDYFGTK VTDNYRWLED
DRSTETENWV KAENEVTFDY LSKIPYRTQL KDRLSELWNF EKVGTPFEEG EYTYYFKNDG
LQNQYVLYRT DKNGKDEVFL DPNTFAEDGT TSLGNLSFTK DGKTLAYSIS EGGSDWQKVI
IMDAETREIK GDTLVDVKFS GISWKGNEGF YYSSYDKPKG SALSAKTDQH KLYFHLLGTP
QSADQVIFGA TPEEKHRYVG GSLTEDDRYL LVSASTSTSG NKLFIKDLSN PKSKLTPIIN
NFDSDTYLIE NKGTKLYLVT NLNAPNKKIV TVDANNPTPE NWKDFIPETE NVLSPSTGGG
FFFTKYMVDA VSKVLQYDYE GKLIREIKLP GVGTAGGFGG KKEEKELYFS FTNYNTPGSS
YKYNVEEGSY ELYWKPSISF NSDDYESKQV FFTSKDGTKV PMIITHKKGL ELNGKNPTIL
YGYGGFNVSL TPGFSIANAV WMEQGGVYAV PNLRGGGEYG KKWHNAGIQM KKQNVFDDFI
AAGEYLIESK YTSSDFLAIR GGSNGGLLVG ATMTQRPDLM KVALPAVGVL DMLRYHTFTA
GAGWAYDYGT SEQSKEMFDY LKGYSPVHNV KSEIEYPATL VTTGDHDDRV VPAHSFKFAA
ELQDKQNGNN PVLIRIETNA GHGAGTPVAK TIEQYADIFG FTLFNMGFDS LPNPPKSKIK
S
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