ID A0A1H4UTV9_9ACTN Unreviewed; 547 AA.
AC A0A1H4UTV9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=SAMN05216482_4357 {ECO:0000313|EMBL:SEC71980.1};
OS Streptomyces sp. PAN_FS17.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1855351 {ECO:0000313|EMBL:SEC71980.1, ECO:0000313|Proteomes:UP000199275};
RN [1] {ECO:0000313|Proteomes:UP000199275}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PAN_FS17 {ECO:0000313|Proteomes:UP000199275};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
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DR EMBL; FNTN01000001; SEC71980.1; -; Genomic_DNA.
DR RefSeq; WP_030967643.1; NZ_FNTN01000001.1.
DR AlphaFoldDB; A0A1H4UTV9; -.
DR STRING; 1855351.SAMN05216482_4357; -.
DR OrthoDB; 3713880at2; -.
DR Proteomes; UP000199275; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR CDD; cd18029; DEXHc_XPB; 1.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF04851; ResIII; 1.
DR PRINTS; PR00851; XRODRMPGMNTB.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000199275}.
FT DOMAIN 189..343
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 397..545
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 547 AA; 60908 MW; F2E5129586476E34 CRC64;
MNGPLIVQSD KTLLLEVDHE QADACRRAIA AFAELERAPE HIHTYRVTPL GLWNARAAGH
DAEQVVDALV TYSRYPVPHA LLVDIADTMD RYGRLTLSKH PTHGLVLTST DRPVLEEVLR
SKRIAPLVGA RIDPDTVAVH PSERGQIKQT LLKLGWPAED LAGYVDGEAH PIELNEDGWA
LRPYQKQAVE NFWHGGSGVV VLPCGAGKTL VGAGSMAQAK STTLILVTNT VSARQWKHEL
VKRTSLTEEE IGEYSGTRKE IRPVTIATYQ VLTTKRKGVY PHLELFDSRD WGLILYDEVH
LLPAPVFKFT ADLQARRRLG LTATLVREDG RESDVFSLIG PKRFDAPWKE IEAQGYIAPA
DCVEVRVNLT ESERLAYATA EQEEKYRFCA TTDTKRKVTE ALVRRFAGQQ ILVIGQYIDQ
LDELGEHLNA PVIKGETSNA QREKLFGAFR EGEISVLVVS KVANFSIDLP EATVAIQVSG
TFGSRQEEAQ RLGRVLRPKA DGHQAHFYSV VARDTIDQDF AAHRQRFLAE QGYAYRIVDA
DEILAEG
//
