ID   A0A1H4UUU0_9ACTN        Unreviewed;      1004 AA.
AC   A0A1H4UUU0;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=Alpha-mannosidase {ECO:0000313|EMBL:SEC71914.1};
GN   ORFNames=SAMN05216489_01447 {ECO:0000313|EMBL:SEC71914.1};
OS   Streptomyces sp. 3213.3.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1855348 {ECO:0000313|EMBL:SEC71914.1, ECO:0000313|Proteomes:UP000198754};
RN   [1] {ECO:0000313|EMBL:SEC71914.1, ECO:0000313|Proteomes:UP000198754}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3213 {ECO:0000313|EMBL:SEC71914.1,
RC   ECO:0000313|Proteomes:UP000198754};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792}.
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DR   EMBL; FNTK01000001; SEC71914.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H4UUU0; -.
DR   STRING; 1855348.SAMN05216489_01447; -.
DR   Proteomes; UP000198754; Unassembled WGS sequence.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   CDD; cd10789; GH38N_AMII_ER_cytosolic; 1.
DR   Gene3D; 2.60.40.2220; -; 1.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR041147; GH38_C.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR   PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF17677; Glyco_hydro38C2; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198754}.
FT   DOMAIN          519..597
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
SQ   SEQUENCE   1004 AA;  111277 MW;  CE39132964A54417 CRC64;
     MHDDRSLVEA RLRRVLEERI RPAVYPESVP LEVAVWHAPD EPVPVAEGLA GTPEPIEVGA
     RWGAPWGTSW FRVTGTVPQE WAGKTVEALL DLGFDENMPG FQCEGLVYRP DGTPVKGLNP
     RNQWVRIGAP VAGGEEVRLY VEAASNPVVM DYHPFVPTQL GDKETAGSEP QYTLTRMDLA
     VLDENVWQLV LDLEVVGELM AELPVDSARR WDLLRAVEKT LDAVDLQDVN GTAEQARSQL
     TAVLSTPAVP SAHRISAIGH AHIDSAWLWP LRETVRKVAR TTSNMTALLE DEPDFIFAMS
     QAQQWAWVKE HRPEVWARVK KAVADGRFVP AGGMWVESDT NMPGSEAMAR QFVHGKRFFL
     DEFGIENEEA WLPDTFGFAA GLPQIIKAAG SKWLLTQKIS WSQTNKFPHH TFRWEGIDGT
     RIFTHFPPVD TYNCSMQGRE IAHAARNFKD KGVARHSLAP TGWGDGGGGT TREMVAKAAR
     LRDLEGSATV AWETPKEFFE KAEAEYPEPP VWVGELYLEL HRATLTSQAK TKQGNRRSEH
     LLREAELWAA TAAVRTGFPY PYEDLDRIWK TVLLHQFHDI LPGSSIAWVH REARKTYEGL
     AAELNGIIDA AQRALAGEGT RELVFNSAPH TRDGVLAGGA QVPAAEGESA LASRVGGGHV
     LENGLLRIEI DGRGLVVSAY DIAADRETVA PGRAANLLQL HPDFPNMWDA WDVDEFYRNT
     VTDLTDVDEV VAEGTAVRIV RSFGASKVTQ VLSLAPGERR LLIDTEVDWH ETEKFLKLAF
     PLDVHAERYA SETQFGHFHR PTHTNTSWEA AKFEACNHRF VHLEEPGWGV SVVNDSTYGH
     DVTRTVRTDG DAGTTTTVRV SLLRAPRFPD PETDQGVHRF RHALVPGAGI GDAVREGWRI
     NLPERRVTGG QEVTPLVSVD RDSVVVTAVK LADDGSGDVV VRFHEAHGGR ARATLTVGFP
     FDSVEVTDLL ERPSADAGEV TREGDQLALR LRPFELVTLR FRRP
//