ID A0A1H4WZ96_9MICC Unreviewed; 288 AA.
AC A0A1H4WZ96;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=3-hydroxybutyryl-CoA dehydrogenase {ECO:0000313|EMBL:SEC97931.1};
GN ORFNames=SAMN04489745_0314 {ECO:0000313|EMBL:SEB48252.1},
GN SAMN04489745_3600 {ECO:0000313|EMBL:SEC97931.1};
OS Arthrobacter woluwensis.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Arthrobacter.
OX NCBI_TaxID=156980 {ECO:0000313|EMBL:SEC97931.1, ECO:0000313|Proteomes:UP000182652};
RN [1] {ECO:0000313|EMBL:SEC97931.1, ECO:0000313|Proteomes:UP000182652}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 10495 {ECO:0000313|EMBL:SEC97931.1,
RC ECO:0000313|Proteomes:UP000182652};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FNSN01000003; SEB48252.1; -; Genomic_DNA.
DR EMBL; FNSN01000007; SEC97931.1; -; Genomic_DNA.
DR RefSeq; WP_066217551.1; NZ_FNSN01000007.1.
DR AlphaFoldDB; A0A1H4WZ96; -.
DR STRING; 156980.SAMN04489745_0314; -.
DR Proteomes; UP000182652; Unassembled WGS sequence.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR022694; 3-OHacyl-CoA_DH.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075:SF3; 3-HYDROXYACYL-COA DEHYDROGENASE; 1.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR PIRSF; PIRSF000105; HCDH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000182652}.
FT DOMAIN 15..183
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 190..286
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT SITE 144
FT /note="Important for catalytic activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR000105-1"
SQ SEQUENCE 288 AA; 31848 MW; AC422052C731B819 CRC64;
MAYDFTFDQI RNRPVTVIGG GTLGRRIALM MASRGGTVRI SDPQQAVAEA AVQYVAETLP
GVLSERGSGE AGTVVAANGL ADALEDAWLV IEAVPERLEI KIPLWGEVDR LAPDDAIFAT
NSSSYASRLM DERIRDKSRF CNLHFYMPPA SNAADVMSDG ETDRAVLDTL LRVLPEFDVH
PFEARKESTG FIFNRVWAAI KRESLAVVAE GVARPEDVDA MFRLNWHMPV GPFQMMDGVG
LDVVLDIEEH YAQENPHLAE GPRTLLREYV EAGKLGRKTG EGFYRYDS
//
