ID A0A1H4X4C5_9PSEU Unreviewed; 383 AA.
AC A0A1H4X4C5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Acetyl-CoA C-acetyltransferase {ECO:0000313|EMBL:SEC99671.1};
GN ORFNames=SAMN04489727_5920 {ECO:0000313|EMBL:SEC99671.1};
OS Amycolatopsis tolypomycina.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Amycolatopsis.
OX NCBI_TaxID=208445 {ECO:0000313|EMBL:SEC99671.1, ECO:0000313|Proteomes:UP000199622};
RN [1] {ECO:0000313|EMBL:SEC99671.1, ECO:0000313|Proteomes:UP000199622}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44544 {ECO:0000313|EMBL:SEC99671.1,
RC ECO:0000313|Proteomes:UP000199622};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Antibiotic biosynthesis. {ECO:0000256|ARBA:ARBA00004792}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
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DR EMBL; FNSO01000004; SEC99671.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H4X4C5; -.
DR STRING; 208445.SAMN04489727_5920; -.
DR OrthoDB; 9764638at2; -.
DR Proteomes; UP000199622; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43365; BLR7806 PROTEIN; 1.
DR PANTHER; PTHR43365:SF1; STEROID 3-KETOACYL-COA THIOLASE FADA6; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:SEC99671.1}.
FT DOMAIN 6..252
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 261..382
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 89
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 339
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 369
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 383 AA; 40880 MW; A1043A65684FFCF2 CRC64;
MPEAFLLDAV RTPVGRRGGA LSGWHPADLA AHVIKAVVER TSVDPDLVDD VILGCTDTLG
PQSGNIARTG WLAAGFGDHV PGVTVDRQCG SSQQAVHFAA QAVMSGTQDL VLAGGVQNMS
RIPISAAMLA GREYGFDDPF SGSKGWQERY GSVEVSQFRS AEMIAEHWDL SRADMEEYAL
RSHQRALSAI DEGRFDAETV PVEDFRHDEG PRRDTSLERM RGLKPLSEGS RLTAAVASQI
SDGASAALLA SEAFVREHGL TPRARIHHLS VRAADPVWML TGPIPATAYA LRKSGLTVAD
IDLFEVNEAF ASVVLAWLDE TGADPDRVNV NGGGIALGHP IGATGTKLLA TLLHELERRG
GRYGLQTMCE GGGTANVTII ERL
//
