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Database: UniProt
Entry: A0A1H4XKE4_9ACTN
LinkDB: A0A1H4XKE4_9ACTN
Original site: A0A1H4XKE4_9ACTN 
ID   A0A1H4XKE4_9ACTN        Unreviewed;       690 AA.
AC   A0A1H4XKE4;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   08-MAY-2019, entry version 9.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:SED06119.1};
GN   ORFNames=SAMN04489844_3587 {ECO:0000313|EMBL:SED06119.1};
OS   Nocardioides exalbidus.
OC   Bacteria; Actinobacteria; Propionibacteriales; Nocardioidaceae;
OC   Nocardioides.
OX   NCBI_TaxID=402596 {ECO:0000313|EMBL:SED06119.1, ECO:0000313|Proteomes:UP000198742};
RN   [1] {ECO:0000313|EMBL:SED06119.1, ECO:0000313|Proteomes:UP000198742}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 22017 {ECO:0000313|EMBL:SED06119.1,
RC   ECO:0000313|Proteomes:UP000198742};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+)
CC         + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|SAAS:SAAS01123908};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|SAAS:SAAS00324886}.
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DR   EMBL; FNRT01000002; SED06119.1; -; Genomic_DNA.
DR   BioCyc; GCF_900105585:BLV76_RS17735-MONOMER; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000198742; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000198742};
KW   Fatty acid metabolism {ECO:0000256|SAAS:SAAS00324839};
KW   Lipid metabolism {ECO:0000256|SAAS:SAAS00324863};
KW   NAD {ECO:0000256|SAAS:SAAS00830857};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00331296};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198742}.
FT   DOMAIN      332    512       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      516    597       3HCDH. {ECO:0000259|Pfam:PF00725}.
SQ   SEQUENCE   690 AA;  72810 MW;  07D4F006FE0FCA4F CRC64;
     MTDIFERARG IVSDAERVTQ AHLRKVTLPG VTFGLITLDN GEDHTKPNTF GPGSLLALNE
     AIDAALADDS VDAIAVTGKP FILAAGADLM SIQGGGPDAV RIVGELGHAT FRKLQDGGKT
     SFGFINGLAL GGGLEVALHC TYRTVMDSAP ALGLPEVMLG LVPGWGGAYL VPNLVGADKA
     VTLILENPLN QGKTLGGQAA YDFGLADAVF NGADFLEQSL LWAASVVRGE TTVTRPDVDR
     GEAWDAAIER ARGIVEARTG GASPAAAKAV ELIAAARDTD RDAGFAAEDD ALEAMSQTAE
     LLASLYSFDL VQKRAKRPAG APDKSLARPV TKVGIVGAGL MASQLALLFV RRLEVPVVLT
     DLDQERADKG VGYVHAEIDK LLAKGRISQD KANRHKALVS GETDKQVAFG DADFVIEAVF
     EEMSVKKTVF ADVEKVVSPE CVLATNTSSL SITEMASDLE HPERVVGFHF FNPVAVMPLL
     EIVRGEATDD ATLATAFATG RTLKKTTILV NDSPSFIVNR LLGRFMSEVG RIVDEGTPVS
     VADGAFAGIA PMPPFVLLSL VGPAIALHNN ETLKGAFPDR FYVSPALERI VAARKASYYG
     PDGALDPAVE ELLVVPESPV VLTSEEVREK TLAGLAEEAR LMLDEGVVAA PQDIDLAMIT
     GAGFSFWNGG LTFMLDVKGI SEKATGKRFH
//
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