ID   A0A1H4Z855_9ACTN        Unreviewed;       353 AA.
AC   A0A1H4Z855;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Adenosine deaminase {ECO:0000313|EMBL:SED25540.1};
GN   ORFNames=SAMN05216482_6661 {ECO:0000313|EMBL:SED25540.1};
OS   Streptomyces sp. PAN_FS17.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1855351 {ECO:0000313|EMBL:SED25540.1, ECO:0000313|Proteomes:UP000199275};
RN   [1] {ECO:0000313|Proteomes:UP000199275}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PAN_FS17 {ECO:0000313|Proteomes:UP000199275};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676}.
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DR   EMBL; FNTN01000001; SED25540.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H4Z855; -.
DR   STRING; 1855351.SAMN05216482_6661; -.
DR   Proteomes; UP000199275; Unassembled WGS sequence.
DR   GO; GO:0019239; F:deaminase activity; IEA:InterPro.
DR   CDD; cd01320; ADA; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR001365; A_deaminase_dom.
DR   InterPro; IPR006330; Ado/ade_deaminase.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR01430; aden_deam; 1.
DR   PANTHER; PTHR43114; ADENINE DEAMINASE; 1.
DR   PANTHER; PTHR43114:SF6; ADENINE DEAMINASE; 1.
DR   Pfam; PF00962; A_deaminase; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000199275}.
FT   DOMAIN          22..345
FT                   /note="Adenosine deaminase"
FT                   /evidence="ECO:0000259|Pfam:PF00962"
SQ   SEQUENCE   353 AA;  38649 MW;  77C138DC54C05ABE CRC64;
     MTDHLVDARV PRDLHAFIAG LPKAELHVHH VGSASPRIVA ELAARHPDSK VPTDPEALAD
     YFTFTDFAHF IDVYLSVVDL IRTPEDVRLL TYEVARDLAR QQVRYAELTI TPFSSTRRGI
     DERAFMAAIE DARKAAEAEF GTVLRWCFDI PGEAGLESAE ETARLATDDR LRPEGLVSFG
     LGGPEIGVPR PQFKPYFDRA IAAGLHSVPH AGETTGPETV WDALTHLRAE RIGHGTSSAQ
     DPKLLAHLAE HRIALEVCPT SNIATRAVRT LDEHPIKEFA KAGIIVTINS DDPPMFGTDL
     NNEYAVAARL LDLDERGLAD LAKNAVTASF LDEPGKARIA EEIDTYTAGW LAP
//