ID   A0A1H5AZQ6_9PSEU        Unreviewed;       356 AA.
AC   A0A1H5AZQ6;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 16.
DE   SubName: Full=Pyruvate dehydrogenase E1 component alpha subunit {ECO:0000313|EMBL:SED47675.1};
GN   ORFNames=SAMN04489727_8024 {ECO:0000313|EMBL:SED47675.1};
OS   Amycolatopsis tolypomycina.
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Amycolatopsis.
OX   NCBI_TaxID=208445 {ECO:0000313|EMBL:SED47675.1, ECO:0000313|Proteomes:UP000199622};
RN   [1] {ECO:0000313|EMBL:SED47675.1, ECO:0000313|Proteomes:UP000199622}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44544 {ECO:0000313|EMBL:SED47675.1,
RC   ECO:0000313|Proteomes:UP000199622};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR   EMBL; FNSO01000004; SED47675.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H5AZQ6; -.
DR   STRING; 208445.SAMN04489727_8024; -.
DR   OrthoDB; 9766715at2; -.
DR   Proteomes; UP000199622; Unassembled WGS sequence.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR   GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR   CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR017596; PdhA/BkdA.
DR   InterPro; IPR029061; THDP-binding.
DR   NCBIfam; TIGR03181; PDH_E1_alph_x; 1.
DR   PANTHER; PTHR43380; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43380:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Pyruvate {ECO:0000313|EMBL:SED47675.1}.
FT   DOMAIN          39..309
FT                   /note="Dehydrogenase E1 component"
FT                   /evidence="ECO:0000259|Pfam:PF00676"
SQ   SEQUENCE   356 AA;  38806 MW;  4ABDB962FEAFE45E CRC64;
     METLLPSAVP VRFVAEDGSR ADRNGGYGEP AGARLKEAYR LMVLGRRFDV QATALTKQGR
     LAVYPSSAGQ EACQVAAALA LEARDWLFPT YRDSVALVAR GLEPGEVLTL LRGDAHCGYN
     PVETRVAPQC TPLATQTLHA AGLAHAMQRR GEDAVALALI GDGATSEGDF HEALNFAAVF
     KAPVVFFVQN NRFAISVPFE KQSAAEALAY KGIGYGMRSE QVDGNDAVAV LAVLDDAVKH
     AREGKGPVLV EAHTYRIDAH TNADDATRYR DAEEVAKWRE ADPLKRLETF LKNENLLQDT
     EIERFAADAE VYAQSVRDTL NAEPELDPLS LFDHVYARPT RQLETQRAAL EAELEA
//