ID   A0A1H5BH63_9PSEU        Unreviewed;       219 AA.
AC   A0A1H5BH63;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=DNA-binding transcriptional regulator, AcrR family {ECO:0000313|EMBL:SED53374.1};
GN   ORFNames=SAMN04489727_8261 {ECO:0000313|EMBL:SED53374.1};
OS   Amycolatopsis tolypomycina.
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Amycolatopsis.
OX   NCBI_TaxID=208445 {ECO:0000313|EMBL:SED53374.1, ECO:0000313|Proteomes:UP000199622};
RN   [1] {ECO:0000313|EMBL:SED53374.1, ECO:0000313|Proteomes:UP000199622}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44544 {ECO:0000313|EMBL:SED53374.1,
RC   ECO:0000313|Proteomes:UP000199622};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FNSO01000004; SED53374.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H5BH63; -.
DR   STRING; 208445.SAMN04489727_8261; -.
DR   OrthoDB; 9806334at2; -.
DR   Proteomes; UP000199622; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProt.
DR   Gene3D; 1.10.357.10; Tetracycline Repressor, domain 2; 1.
DR   InterPro; IPR039538; BetI_C.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   PANTHER; PTHR30055; HTH-TYPE TRANSCRIPTIONAL REGULATOR RUTR; 1.
DR   PANTHER; PTHR30055:SF164; TRANSCRIPTIONAL REPRESSOR MCE3R; 1.
DR   Pfam; PF13977; TetR_C_6; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   SUPFAM; SSF48498; Tetracyclin repressor-like, C-terminal domain; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00335,
KW   ECO:0000313|EMBL:SED53374.1}; Repressor {ECO:0000256|ARBA:ARBA00022491};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          18..78
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50977"
FT   DNA_BIND        41..60
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   219 AA;  23468 MW;  D8D716EEE3CD0A1D CRC64;
     MTRVDRAAEG RIQDDGEGIV EARILDAAAH LIAEEGFGRL KVGSVCARSG YARSVIFQHF
     GDKDGLGQRL VEHAVEEFTD AYSEAVAART GSANATPMDM LRALLDIIFE LIRTMPTLNQ
     AFLALWGDAA AEYSGLRGAL TEADRRFRFA IAQTVASGVA DGSITGVHDP DSYASALLAQ
     LRGISMQALI DPDGVDLRGL RAELERSVDR LSAGFRGSL
//