ID   A0A1H5BV66_9ACTN        Unreviewed;       418 AA.
AC   A0A1H5BV66;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Thioredoxin reductase {ECO:0000313|EMBL:SED58443.1};
GN   ORFNames=SAMN05216489_03846 {ECO:0000313|EMBL:SED58443.1};
OS   Streptomyces sp. 3213.3.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1855348 {ECO:0000313|EMBL:SED58443.1, ECO:0000313|Proteomes:UP000198754};
RN   [1] {ECO:0000313|EMBL:SED58443.1, ECO:0000313|Proteomes:UP000198754}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3213 {ECO:0000313|EMBL:SED58443.1,
RC   ECO:0000313|Proteomes:UP000198754};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide +
CC         H(+) + NADPH; Xref=Rhea:RHEA:20345, Rhea:RHEA-COMP:10698, Rhea:RHEA-
CC         COMP:10700, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.8.1.9;
CC         Evidence={ECO:0000256|ARBA:ARBA00000849};
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DR   EMBL; FNTK01000001; SED58443.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H5BV66; -.
DR   STRING; 1855348.SAMN05216489_03846; -.
DR   Proteomes; UP000198754; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   PANTHER; PTHR48105; THIOREDOXIN REDUCTASE 1-RELATED-RELATED; 1.
DR   Pfam; PF13738; Pyr_redox_3; 1.
DR   PRINTS; PR00368; FADPNR.
DR   PRINTS; PR00469; PNDRDTASEII.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198754}.
SQ   SEQUENCE   418 AA;  44939 MW;  A3971DD0CCAA43FC CRC64;
     MYDLLVVGAG PYGLSIASHA AAAGLNLRVF GRPMASWRDH MPRGMFLKSE PWASNLSDPE
     GRWPLEKYCA GQGVEARHGE PIPVEMFASY GLWFARNAVP EVDERTVERI APVPGGFEAV
     TDDGTVLHAR TVALAVGVMP FVEIPSALRG LSRSLVSHSS HHSALDDFRG KDVTVIGGGQ
     AALETAALLA EQGTRVRVLA RADELHWNDV PPAWERPWWQ EARSPHSGLG PGWRNWFYAE
     RPDLFRRLPE STRARIAANA LGPAGAWWVR DRVEPAVEVL LGHEVAAADL VPGGVRLETV
     SGAGGTRSLE TEHVIAATGF KATTGRLGLL SSELRGSLAT VGDGSPEVGR DFESSHPGLF
     MAGLLTASGF GPAMRFVHGA TFTAGALVRG VRRRLRSEPR GGMIPAPGRR GALDFVRR
//