ID   A0A1H5C1T2_9MICO        Unreviewed;       351 AA.
AC   A0A1H5C1T2;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Adenosine deaminase {ECO:0000313|EMBL:SED60240.1};
GN   ORFNames=SAMN04488554_0243 {ECO:0000313|EMBL:SED60240.1};
OS   Ruania alba.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Ruaniaceae; Ruania.
OX   NCBI_TaxID=648782 {ECO:0000313|EMBL:SED60240.1, ECO:0000313|Proteomes:UP000199220};
RN   [1] {ECO:0000313|Proteomes:UP000199220}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 21368 {ECO:0000313|Proteomes:UP000199220};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676}.
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DR   EMBL; FNTX01000001; SED60240.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H5C1T2; -.
DR   STRING; 648782.SAMN04488554_0243; -.
DR   OrthoDB; 9779574at2; -.
DR   Proteomes; UP000199220; Unassembled WGS sequence.
DR   GO; GO:0019239; F:deaminase activity; IEA:InterPro.
DR   GO; GO:0016814; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines; IEA:UniProt.
DR   GO; GO:0009168; P:purine ribonucleoside monophosphate biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR001365; A_deaminase_dom.
DR   InterPro; IPR006330; Ado/ade_deaminase.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR01430; aden_deam; 1.
DR   PANTHER; PTHR43114; ADENINE DEAMINASE; 1.
DR   PANTHER; PTHR43114:SF6; ADENINE DEAMINASE; 1.
DR   Pfam; PF00962; A_deaminase; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR   PROSITE; PS00485; A_DEAMINASE; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000199220}.
FT   DOMAIN          18..348
FT                   /note="Adenosine deaminase"
FT                   /evidence="ECO:0000259|Pfam:PF00962"
SQ   SEQUENCE   351 AA;  37305 MW;  15B6E818FADD1BD5 CRC64;
     MRELSYSGTV ARDLRALPKA HLHLHFTGSM NAHTLSDLAT EAGVQLPETL REAVAADALR
     LPANERGWFR FQRMYDAARA VVRSEAAMRR LVHEAARADA DEGSRRLEIQ VDPTSYAPFV
     GGITPALEIV TDAAREASAI TGVEIGVIVA SSRTRHPLDA RTLARLAVRH AGDGPGEVIG
     FGLSNDERRG TTSEFGPAFR IAARAGLLLA PHGGELLGPD HVAEVVAHLH PDRLGHGVRA
     AEDPALLDRI VADGIGLEVC PASNVSLGVF STAEQVPLRR LLTAGANIAL GADDPLLFGS
     RLLAQYETAR HVHGLTDAEL AELARGSIRA SRASQTSRTA MLADVDAWLA A
//