ID A0A1H5EDT0_9MICO Unreviewed; 353 AA.
AC A0A1H5EDT0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727};
DE EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727};
GN ORFNames=SAMN04488554_0982 {ECO:0000313|EMBL:SED89166.1};
OS Ruania alba.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Ruaniaceae; Ruania.
OX NCBI_TaxID=648782 {ECO:0000313|EMBL:SED89166.1, ECO:0000313|Proteomes:UP000199220};
RN [1] {ECO:0000313|Proteomes:UP000199220}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21368 {ECO:0000313|Proteomes:UP000199220};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003};
CC -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC {ECO:0000256|ARBA:ARBA00007572}.
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DR EMBL; FNTX01000001; SED89166.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H5EDT0; -.
DR STRING; 648782.SAMN04488554_0982; -.
DR OrthoDB; 9770771at2; -.
DR Proteomes; UP000199220; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd07905; Adenylation_DNA_ligase_LigC; 1.
DR CDD; cd07970; OBF_DNA_ligase_LigC; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR044119; Adenylation_LigC-like.
DR InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR044117; OBF_LigC-like.
DR PANTHER; PTHR45674; DNA LIGASE 1/3 FAMILY MEMBER; 1.
DR PANTHER; PTHR45674:SF9; DNA LIGASE 3; 1.
DR Pfam; PF04679; DNA_ligase_A_C; 1.
DR Pfam; PF01068; DNA_ligase_A_M; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:SED89166.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000199220}.
FT DOMAIN 124..243
FT /note="ATP-dependent DNA ligase family profile"
FT /evidence="ECO:0000259|PROSITE:PS50160"
SQ SEQUENCE 353 AA; 39359 MW; 52A17A75A33094E9 CRC64;
MDLPISLPIT PMLAKAAKAV PAADAVAGGY SYEPKWDGFR GILLRDGDEV EIASRGSKPL
TRYFPELVEA IREHLPSRCA IDGEIVVRSG EPGAQRLDWE ALSQRIHPAE SRVQRLAAET
PAEFVAFDLL ALEDEDLMEV PFEQRRTRLA EVLGELATDA PIHLTRVTDD QAVAEDWFER
FEGAGLDGVI AKPNRSVYQP GKRTMIKVKH SRTAEAVAVG YRVHKSGQGV GSLLLGLYTD
DGQLINVGGI AAFTNARRLE LVDELEPFVQ RDDDGDAVRG ETDRSRFSSN KDVSFVRLRP
ERVVEVKFDQ LEGHRFRHAV TFLRWRPDRD PASCTLDQVD RAMAYDLGEV LTR
//
