ID   A0A1H5GB64_9MICO        Unreviewed;      1026 AA.
AC   A0A1H5GB64;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Alpha-mannosidase {ECO:0000313|EMBL:SEE12885.1};
GN   ORFNames=SAMN04488554_1596 {ECO:0000313|EMBL:SEE12885.1};
OS   Ruania alba.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Ruaniaceae; Ruania.
OX   NCBI_TaxID=648782 {ECO:0000313|EMBL:SEE12885.1, ECO:0000313|Proteomes:UP000199220};
RN   [1] {ECO:0000313|Proteomes:UP000199220}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 21368 {ECO:0000313|Proteomes:UP000199220};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792}.
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DR   EMBL; FNTX01000001; SEE12885.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H5GB64; -.
DR   STRING; 648782.SAMN04488554_1596; -.
DR   OrthoDB; 9772207at2; -.
DR   Proteomes; UP000199220; Unassembled WGS sequence.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   CDD; cd10789; GH38N_AMII_ER_cytosolic; 1.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR041147; GH38_C.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR   PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF17677; Glyco_hydro38C2; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199220}.
FT   DOMAIN          527..605
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
SQ   SEQUENCE   1026 AA;  112808 MW;  0A807FBB5C0A53BE CRC64;
     MHRTITDLGA RVDRALTERV TPAVHSYRTP VVVAAHVLAG EPVPFAEAVA GEFTPFAVGT
     DWGRPWGTTW FRFTGTVGEA IRAHAEEQRI ELLVDLGFGP GGPGFRSEGL AYTADGTILK
     AVEPRTAYVP VGGERGAPIA ADGTFEVYLE AASNPRFDGT VSSLGDLDTA GDTPLYRLER
     AELALREPEV HHLLIEARLL HQIAATTPES DPRHHELRYA LDRMVDELDA GGFDRVASSA
     PAARAQLAGV LADRARTSAH TVSAVGHAHI DSAWLWPVRE TIRKCSRTFS NVIALAQEYP
     EFIFACSSAQ QYAWMRDHHP QVWERVREAV AAGTFVPVGG MWVESDTNLP GGEALVRQFT
     AGKRFFAEHF GTEAREVWLP DSFGYSGSLP QLARLAGFDW FLSQKMSWNS TNPFPHHTFW
     WEGIDGTRVF THFPPSDTYS SEFNGPELAR STTQFRENGR ATRSLLPFGY GDGGGGPTRE
     MLETARRLAD LDGAPKVHIE TPEEFFTAAH AEYGEHAPVW SGEMYLEFHR GTYTSQRAMK
     EGNRRTEHLL HEAELWSATA TVRHGTPYPA DELDRIWEEV LLLQFHDILP GSSIAWVHRE
     ARERYAALTA RLEALIDGAL EVLAGTGEVP LAFNATPHPH DGVPPLGGAA PRRDATAVQT
     HQADGEVHLD NGLLRVRIGT DGTVVSVWDH GADREVLAGP GNALWLHPDT PNRFDAWDLD
     EFYRHTGHAL TAVDRIEVDS SDPARPVVRI TRTDGGSTYR QEVALAAGSI ALECTTEVDW
     HERERILKVA FPLDVHARES TAETQFGYVQ RPTHTNTSWD AAKFEIPAHK WLHVGEPGYG
     VAVTNEATYG HEATRPGPGE ARGAGATTVR LSLLRAPRYP DPQTDQGRHV LRYQLVCGAD
     LPEAIRAGYR TGRPLRERRG AGGVEPLVAI EDGPVLLETV KLADDGSGDL VLRLYESRGG
     RGRAELTVAE DVQMRDAVVT DLLERPDEQI AALAPLERDG DRLTLDLTPF QVVTVRITRS
     SAGRQS
//