ID A0A1H5JL37_9FLAO Unreviewed; 776 AA.
AC A0A1H5JL37;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=SAMN04487765_2977 {ECO:0000313|EMBL:SEE53206.1};
OS Tenacibaculum sp. MAR_2010_89.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Tenacibaculum.
OX NCBI_TaxID=1250198 {ECO:0000313|EMBL:SEE53206.1, ECO:0000313|Proteomes:UP000198792};
RN [1] {ECO:0000313|EMBL:SEE53206.1, ECO:0000313|Proteomes:UP000198792}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mar_2010_89 {ECO:0000313|EMBL:SEE53206.1,
RC ECO:0000313|Proteomes:UP000198792};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; FNUB01000005; SEE53206.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H5JL37; -.
DR STRING; 1250198.SAMN04487765_2977; -.
DR Proteomes; UP000198792; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000198792}.
FT DOMAIN 6..291
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 292..572
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 27..34
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 776 AA; 88680 MW; 9A21E6025C534CF5 CRC64;
MNTYLEQLNE PQRAAVLQKD GPMIIIAGAG SGKTRVLTFR IAHLMQGGVD SFNILSLTFT
NKAAREMKER IGSVVGYSEA KNLWMGTFHS VFARILRSES DKLGYPSNFT IYDSQDSVRL
ITAIIKEMNL DKDRYKPKQI LGRISSFKNS LITVRAYFNN SDLQEADLQA SRPKVGEIYK
EYVDRCFKSG AMDFDDLLLR TNELLARFPE VLAKYQDRFR YIMVDEYQDT NHSQYLIVRA
LADRFQNICV VGDDSQSIYS FRGANINNIL NFQKDYPDVK TFKLEQNYRS TNNIVEAANS
VIDKNKTKLD KEVWTANDPG ESIKIMRTIS DGEEGRFVAQ SIWENQMNHQ LTNNDFAILY
RTNAQSRAME DALRKKDIKY KIYGGISFYQ RKEIKDLLSY LRILINPNDE EALKRIINYP
ARGIGATTLD KLAIAANHYK KSIFDIIKHI DKIDIKINSG TKTKLQNFIN MMQRLQIEAQ
TKNAFEMADL VVKQTQLVKD LQKDGTPEGV NKVENVQELL NGIKDFITDK IETGEDASLT
SFLEDVALAT DFDSEKDDTP RVSLMTIHLS KGLEYPYVYI VGLEESLFPS AMSMNTRNEL
EEERRLFYVA LTRAEKVAYL TYAQTRYRWG KLTDGEPSRF LEEIDEKYVE YLAPKVPEPS
ANRFIDASLF GDEDSSKKIR FQKPIQKKRK EFLAKKEKAT MVPPKSKMKK VSEATSKTNL
FDGEIVVGNI VEHNRFGTGK VLALDGKGPN KKAEIEFGTV GKKKLLLQFA KLKVIG
//
