ID A0A1H5K221_9FLAO Unreviewed; 1831 AA.
AC A0A1H5K221;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Alpha-2-macroglobulin family N-terminal region {ECO:0008006|Google:ProtNLM};
GN ORFNames=SAMN04487765_3271 {ECO:0000313|EMBL:SEE58886.1};
OS Tenacibaculum sp. MAR_2010_89.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Tenacibaculum.
OX NCBI_TaxID=1250198 {ECO:0000313|EMBL:SEE58886.1, ECO:0000313|Proteomes:UP000198792};
RN [1] {ECO:0000313|EMBL:SEE58886.1, ECO:0000313|Proteomes:UP000198792}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mar_2010_89 {ECO:0000313|EMBL:SEE58886.1,
RC ECO:0000313|Proteomes:UP000198792};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC {ECO:0000256|ARBA:ARBA00010556}.
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DR EMBL; FNUB01000005; SEE58886.1; -; Genomic_DNA.
DR STRING; 1250198.SAMN04487765_3271; -.
DR Proteomes; UP000198792; Unassembled WGS sequence.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd02891; A2M_like; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR021868; Alpha_2_Macroglob_MG3.
DR InterPro; IPR041203; Bact_A2M_MG5.
DR InterPro; IPR041462; Bact_A2M_MG6.
DR InterPro; IPR041246; Bact_MG10.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF17973; bMG10; 1.
DR Pfam; PF11974; bMG3; 1.
DR Pfam; PF17972; bMG5; 1.
DR Pfam; PF17962; bMG6; 1.
DR Pfam; PF01835; MG2; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000198792}.
FT DOMAIN 968..1110
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 1174..1264
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
SQ SEQUENCE 1831 AA; 206570 MW; 4AB4CDC63C96E1E6 CRC64;
MKRVYQIIIL LVFVLGVQSC KKNESKASNV HDYSEYVSVF PENLISTTSS LDFLLKNKAN
VADVKNDVFT ITPKVKGTVV LKDNLLTFVP SEKLKSNQEY NVTLHLSKLY DGIDSNLKDF
TVKIKTKKLL FNVALKSPTV LNKDEYYIEG VLTASDVIES SKLSELVSAS YNGKATDIKF
DTSEEFVSKA TFKIDKLKRF EDDKSINVLW NGKAINSVSK GERELSITGK NNFKVLNIEV
VDTEKQHIEI SFSDAIKKNQ DLKGLIQFVN TQKRYFTYAI NNNIVTIYPK AAFKNKVDIE
IFKGLKSIDG YALKESYSKT LHFKQLNPLV SFIKSGTIIP NSKNLKINFK AVNLKAVDAT
IYKIYKDNVL QFLQYNNLSN KGNLRYVGRP VASYTVNLTN QGVDLTKENA FAIDLAEIIT
VENGAMYRVE LSFKKEYSNY TCDETLSTTT IVYGKKEVNT KAFDNPNYYN DNYRSYRWSD
RKNPCTESYF YNKNISTNIL ATNLGVIVKK GNNNTTFIAV TDLLTTKPVE GAKVTLYNLQ
QQPVIETTTD KEGIVKIEGI TNAFFAVVTK NNNTTYIKLN DGNSLSMSKF DVSGVKLQKG
IKGYIYGERG VWRPGDQLFL TFVLNDNANP IPEKHPIKFE LINPQGKITE RKILFKIPKN
VYAYSPKTNR DAITGNWKLR VSVGGAVFNK NLKIETIKPN RLKIKLNTKA DFIKANTSID
GDVEVKWLHG AIARNLKLDI NGKFTQTVTA FPKYSNYKFD DITRRFGTEE FKVLKGVLNN
EGKTTFSVKP RLANKAPGML KASFITKVYE NGGDFSTDVF SKKVSPYTSY VGLLNAEEQQ
SRNYLFTDEK YTFNVASVND LGVGIRNNLE VKVYKLSWRW WWSTSDNGLS NYDGTRYHQP
YKTLQVKTNA TGKGSFDLKV DEGDWGRYLI KVRDKKSKHV TSNIAYFDWP SWYGKKKGSQ
DKTNATMLVF TTDKESYQVN ETATVKFPSS EGGRALITIE NGVEVLDNFW VETKAKQTEF
SFPVLANYTP NVFVNISLLQ KHSQTVNDLP IRMYGSIPML VNDPATKLEP EISIADELRP
ESVATIKVKE KKGKAMTYTI ALVDDGLLDL TRFKTPNPWS TFYARQSLGV KTWDIFDDVV
GAYGGKVNQI LSIGGDEAEA GSKNKKANRF KPMVVYLGPF HLEKGDTKEH VVKIPKYVGS
VRAMVVATDI KKEAYGSDEK TSFVRKPVMI LASLPRKITP KETVTLPVTV FAMKPSVKKV
KVTVKPNESY TIIGDKTQTV TFNQPDEKMA YFTLKVNDFK GIGKVNIEAS SGNEKASYEV
EIDVLNPNPV TTEVKDLILK SNEQSEINFS TFGTQGTNAV GIELSTLPPM NFTKRMGYLI
QYPHGCVEQT TSSAFPQLFL SEIFELPVEK KQSIERNIKA TIQRLSNFQL SNGGLSYWQG
SGNANSWGTS YAGHFMIEAA KKGYVLPIGF RSKWIEYQKQ ESRNWRNNSR YYNNALTQAY
RLYTLSLANS PDLASMNRLR ETNSISNEAK MRLAAAYALL GKKSIAKLIL NSLSSQNYSK
RYYYNYGSET RNKAMALETY TLLNEETKAI KLAKEIAETL SSENWMSTQT TSYSLLAISQ
YALQNGESSG INASYSFNNN IEKINTSKAL FIKDLVGLQK DNKLKVSNKN KGVLYVRVFN
KGILPVGEEK VVQKNLEATV VYKSKEGVKV EPNSLSQGTN FVAEVSVRNS TNEKVENVAL
TQFIPSGWEI INTRFTDFGN NTNSSKVDYT DIRDASISNY FTLNKFETKT FRVLLNASYL
GEYYLPGIQV EAMYDNDYIA RNKGQWVKVM K
//
