UniProt: A0A1H5KP32

Database: UniProt
Entry: A0A1H5KP32_9ACTN

LinkDB:  A0A1H5KP32_9ACTN 
Original site:  A0A1H5KP32_9ACTN

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Ontology (3)   
   GO (3)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (25)   
   InterPro (14)   
   Pfam (6)   
   PROSITE (2)   
   SMART (3)   
All databases (29)   

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ID   A0A1H5KP32_9ACTN        Unreviewed;      2284 AA.
AC   A0A1H5KP32;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=Polyketide-type polyunsaturated fatty acid synthase PfaA {ECO:0000313|EMBL:SEE66639.1};
GN   ORFNames=SAMN05216489_07689 {ECO:0000313|EMBL:SEE66639.1};
OS   Streptomyces sp. 3213.3.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1855348 {ECO:0000313|EMBL:SEE66639.1, ECO:0000313|Proteomes:UP000198754};
RN   [1] {ECO:0000313|EMBL:SEE66639.1, ECO:0000313|Proteomes:UP000198754}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3213 {ECO:0000313|EMBL:SEE66639.1,
RC   ECO:0000313|Proteomes:UP000198754};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FNTK01000001; SEE66639.1; -; Genomic_DNA.
DR   STRING; 1855348.SAMN05216489_07689; -.
DR   Proteomes; UP000198754; Unassembled WGS sequence.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:UniProt.
DR   GO; GO:0018580; F:nitronate monooxygenase activity; IEA:InterPro.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd00833; PKS; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   Gene3D; 1.10.1200.10; ACP-like; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 2.
DR   Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR004136; NMO.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43074; OMEGA-3 POLYUNSATURATED FATTY ACID SYNTHASE PFAB-RELATED; 1.
DR   PANTHER; PTHR43074:SF1; PKS_AT DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF08659; KR; 1.
DR   Pfam; PF03060; NMO; 2.
DR   Pfam; PF00550; PP-binding; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00822; PKS_KR; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SUPFAM; SSF47336; ACP-like; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   SUPFAM; SSF51412; Inosine monophosphate dehydrogenase (IMPDH); 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR   SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 1.
DR   PROSITE; PS50075; CARRIER; 1.
DR   PROSITE; PS52004; KS3_2; 1.
PE   4: Predicted;
KW   Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198754};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          672..1113
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          1692..1771
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   2284 AA;  237932 MW;  5DEAB577D91D2C60 CRC64;
     MTSVARAAEM IIGITPFHEP DARLAAAVSR AGGLGVLDLG IGDRRSREAL ARIRRWAPGP
     FGVRVGAHCR IDPAELATTA DGGPHTVVLT VDTAWRVEEV ADAYRVLVEV TDPDQALTAV
     RSGAHGLIAR GAESGGRIGE LSTFVLLQRL LAEPGVTVPV WACGGIGPRT AAAAVAGGAA
     GVVLDSQLAL LAESALPETA AAALRSMDGS ETTVIAGHRV LLRRGPDAPQ VPAERVSELL
     GARDPRTQLL PVGQDGFLAA RFAERWGDVG RTVRELTAAV RESIRDEGPA GALRAGSPMS
     RRIGTQLPLA QGPMTRVSDQ AEFAAAVAGG GALPFVALAL ASGEQSRTVL AETRAALGDR
     PWGVGVLGFA PEEMRNAQLE AVRELRPTHA IVAGGRPSQA EALERSGIAT FLHVPSPGLL
     RQFLDAGVRR FVFEGSECGG HVGPRGSFPL WEAQLAVLDD FLETAAAGTA EHVEVFFAGG
     VHDERSAAMV AALAAPLTAR GAAVGVLMGT AYLFTEEAVT RGAVQPLFQE QVVRATRTAL
     LETAPGHATR CVPSPFSDNY LLFEAELREQ GVPDRQIWEK LERLNVGRLR IASKGVERDA
     AGALTSVDEE RQLAEGMFMA GEVAVLRSAT TTIDALHRSV TEGAADFLAD SARTARVLLG
     VEEQAEPEPP APLDIAVIGM ACMFPEAPDL PTFWANILGG RDAVTEVPAD RWDPAVHYAD
     DKSGATPSKW GGFLPRIPFD PLRYGIPPTS LGSIEPVQLL ALEAARRSLE DAGYGDRGRH
     FDRARTSVVF GAEAGSDLSN ATTLRAVLPS YYGRIPQGIE EQLPTLTEDS FPGMLSNVIS
     GRIANRLDLG GANFTVDAAC ASSLAAVDVA CKELVGGTSD IVLCGGADLH NGINDYVLFS
     SVHALSPTGR SRAFDNSADG IALGEGVACV VLKRLADAER DGDRIYGVIK GVGSSSDGRS
     LGLTAPRPEG QRAALERAYR NAGVSPASVG LVEAHGTGTV VGDRTELSIL SEVFTESGAE
     TGSCALGSVK SQIGHTKCAA GLAGLIKTVL SLYTGVKPPT LHMKQPNSAW KEDDSPFVFH
     ARPRPWAAPA EERVAGLSAF GFGGTNFHTV IQAYGDAVPP AHGLDAWPAE LFIFRGADRA
     AARRGIEETL KLAESGSWRL RDLALGASRR SDARHEPVQV AVVATGVEEL AGQLRRALAG
     EHDPGAGIHA ADLQEDAGKV AFLFPGQGSQ RPGMLADVFI AFPELQHYLH LGRDHADTLY
     PPTAFDDTAR DRQQAGLTDT RVAQPTLGIA GLAAHALLTE AGVRPDMAAG HSYGELVALC
     AAGAIAPEAL LELSAERAAA ILEATGADDP GTMAAVAAGA EDVEQALKTA GAPDSVVLAN
     HNSPRQTVIS GPTAAVAEAV RLLREAGLGA KRIPVACAFH SPLVAGAGER FARALAQQAV
     LTPEFPVWSN RTAAPYGEGA DAVRAELAAQ IGAPVGFVAQ IEAMYEAGAR VFVEAGPGSV
     LTRLVAQILG ERPHRTVACE PRPDSGLRGW LDALAQLAVA GLPVRTGWLF NGRDAVDAAR
     TPVPKRPGWT VDGQLVRTAA GELLPGALAP ARRVVETTVT TNPQGGAPVE ANRDALISEF
     LRTSREMVAA QRDVLLTYFG ATQATVPQGT WVPAPAPAAV EALPQLPALP AAAEAPVAQQ
     STAQPESVPE AVTEDDVLRV VLEIISERTG YPVDMIEPDL DLEADLSIDS IKRAEIAGEL
     AQRLGIGGGA DIASLDDAEL EDLAKARTAA SVTGWLSARL TEPAAPAADT SPQDEVTGSA
     PKRLQLRPVL LPHQDSDNPA DPASVLSGRR FVLYGAGDVP EAVAARLSSY GADTVIVAPE
     HQLTDADGQV DGVLYLAPLT ASAPVLPDAF PVFQAVLRRA PRQLIAVQGA ESGSAGLHGL
     FRTVAREYPD TVARIVEVAD PASAAIADAV LAELLAPGDE PVVLRTAVGR HGLELTETPL
     GALATNGAGP AGDGVAEAAA IGLDRDAVVL LVGGARGITA KFAVALAAAS RCRIELLGRT
     TAPAGPEDPA TAGARTPAEL RAALAGQGGR TPAEINRTAE LLLAQREITA TLDELAALGS
     EARYHSVDFR EPDAALQAVK EIHAEHGRLD GVVYAAGVIE DRLIAEKTTE SFQRVYGTKT
     HGAETLLSAL EELPNGPAFA VLFGSISAVL GNRGQVDYAA ANDALESLGT AWSARTGHRA
     LTVHWGPWAP TGGHHGMVTP ELGREYARRG ISLIDPEEGT AALLRELAFG DESAGAVVYT
     ASGW
//

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