ID   A0A1H5L402_9ACTN        Unreviewed;       374 AA.
AC   A0A1H5L402;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 13.
DE   SubName: Full=IMP dehydrogenase {ECO:0000313|EMBL:SEE71714.1};
GN   ORFNames=SAMN05216533_3383 {ECO:0000313|EMBL:SEE71714.1};
OS   Streptomyces sp. Ag109_O5-10.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1855349 {ECO:0000313|EMBL:SEE71714.1, ECO:0000313|Proteomes:UP000198812};
RN   [1] {ECO:0000313|EMBL:SEE71714.1, ECO:0000313|Proteomes:UP000198812}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ag109_O5-10 {ECO:0000313|EMBL:SEE71714.1,
RC   ECO:0000313|Proteomes:UP000198812};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the IMPDH/GMPR family.
CC       {ECO:0000256|ARBA:ARBA00005502}.
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DR   EMBL; FNTQ01000001; SEE71714.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H5L402; -.
DR   STRING; 1855349.SAMN05216533_3383; -.
DR   OrthoDB; 9805398at2; -.
DR   Proteomes; UP000198812; Unassembled WGS sequence.
DR   GO; GO:0003938; F:IMP dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006164; P:purine nucleotide biosynthetic process; IEA:InterPro.
DR   CDD; cd00381; IMPDH; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR005990; IMP_DH.
DR   InterPro; IPR005992; IMP_DH-rel2.
DR   InterPro; IPR001093; IMP_DH_GMPRt.
DR   NCBIfam; TIGR01304; IMP_DH_rel_2; 1.
DR   PANTHER; PTHR11911:SF111; INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE; 1.
DR   PANTHER; PTHR11911; INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED; 1.
DR   Pfam; PF00478; IMPDH; 1.
DR   SMART; SM01240; IMPDH; 1.
DR   SUPFAM; SSF51412; Inosine monophosphate dehydrogenase (IMPDH); 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000198812}.
FT   DOMAIN          15..297
FT                   /note="IMP dehydrogenase/GMP reductase"
FT                   /evidence="ECO:0000259|Pfam:PF00478"
SQ   SEQUENCE   374 AA;  39916 MW;  61948C1DA4BA1CE6 CRC64;
     MTEIEIGRGK RGRRAYAFDD IAVVPSRRTR DPKEVSIAWQ IDAYRFELPF LAAPMDSVVS
     PATAIRIGEL GGLGVLNLEG LWTRHEDPQP LLDEIIGLDS DTATRRLQEI YAAPIKEELI
     GARIKEVRDS GVVTAAALSP QRTAQFSKAV VDAGVDIFVI RGTTVSAEHV SSSHEPLNLK
     QFIYELDVPV IVGGCATYTA ALHLMRTGAA GVLVGFGGGA AHTTRNVLGI QVPMATAVAD
     VAAARRDYMD ESGGRYVHVI ADGGVGWSGD LPKAIACGAD SVMMGSPLAR ATDAPGKGHH
     WGMEAVNEEL PRGKKVDLGT VGTLEEILTG PSHTPDGSMN LFGALRRAMA TTGYSELKEF
     QRVEVTVADA QHKR
//