ID A0A1H5M1G4_9FLAO Unreviewed; 370 AA.
AC A0A1H5M1G4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=ATP-dependent metalloprotease FtsH {ECO:0000313|EMBL:SEE83159.1};
GN ORFNames=SAMN04488034_102516 {ECO:0000313|EMBL:SEE83159.1};
OS Salinimicrobium catena.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Salinimicrobium.
OX NCBI_TaxID=390640 {ECO:0000313|EMBL:SEE83159.1, ECO:0000313|Proteomes:UP000199448};
RN [1] {ECO:0000313|EMBL:SEE83159.1, ECO:0000313|Proteomes:UP000199448}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 23553 {ECO:0000313|EMBL:SEE83159.1,
RC ECO:0000313|Proteomes:UP000199448};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the AAA ATPase family.
CC {ECO:0000256|RuleBase:RU003651}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the peptidase M41
CC family. {ECO:0000256|ARBA:ARBA00010044}.
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DR EMBL; FNUG01000002; SEE83159.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H5M1G4; -.
DR STRING; 390640.SAMN04488034_102516; -.
DR Proteomes; UP000199448; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.20.58.760; Peptidase M41; 1.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000642; Peptidase_M41.
DR InterPro; IPR037219; Peptidase_M41-like.
DR PANTHER; PTHR43655; ATP-DEPENDENT PROTEASE; 1.
DR PANTHER; PTHR43655:SF2; SD01613P; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF01434; Peptidase_M41; 1.
DR SUPFAM; SSF140990; FtsH protease domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00674; AAA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU003651};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000313|EMBL:SEE83159.1};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU003651};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:SEE83159.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000199448}.
FT DOMAIN 2..98
FT /note="ATPase AAA-type core"
FT /evidence="ECO:0000259|Pfam:PF00004"
FT DOMAIN 121..164
FT /note="AAA ATPase AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17862"
FT DOMAIN 180..363
FT /note="Peptidase M41"
FT /evidence="ECO:0000259|Pfam:PF01434"
SQ SEQUENCE 370 AA; 41245 MW; F2B683115D702B3C CRC64;
MFVGVGAARV RDLFKKAKAQ TPSIIFIDEI DTIGRARSGT SVFHESDERD STLNQLLAEL
DGFGTNTGVI VLAATNRGDI LDPALLRPGR FDRHIQLELP NQTERKAIFE VHMKPLALDA
DVDVGMLAAQ TPGFSGADIA NICNEAALIA THRQKELIQK QDFLDAIDRV IGGMEKRSKI
ISPEEKKRIA FHEAGHVTTS WFLKHAQPVH KVSIIPRGKS LGSAWYLPEE HQIVTKSEFF
DALCTALGGR AAEEIFFEEI SSNAVDDLEK ATKQAYSMVM NYGLSDVLRN LSFYDSTGKL
RQSLHKPYSE KTAEKIDEEV QAIIDKAFAT SKEILTTHRE RVENLAARLM EKETLQKEEI
KEILGERVTA
//
