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Database: UniProt
Entry: A0A1H5M635_9ACTN
LinkDB: A0A1H5M635_9ACTN
Original site: A0A1H5M635_9ACTN 
ID   A0A1H5M635_9ACTN        Unreviewed;       388 AA.
AC   A0A1H5M635;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   11-DEC-2019, entry version 14.
DE   RecName: Full=Xylose isomerase {ECO:0000256|HAMAP-Rule:MF_00455, ECO:0000256|RuleBase:RU000609};
DE            EC=5.3.1.5 {ECO:0000256|HAMAP-Rule:MF_00455, ECO:0000256|RuleBase:RU000609};
GN   Name=xylA {ECO:0000256|HAMAP-Rule:MF_00455};
GN   ORFNames=SAMN05216489_08549 {ECO:0000313|EMBL:SEE83898.1};
OS   Streptomyces sp. 3213.3.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1855348 {ECO:0000313|EMBL:SEE83898.1, ECO:0000313|Proteomes:UP000198754};
RN   [1] {ECO:0000313|EMBL:SEE83898.1, ECO:0000313|Proteomes:UP000198754}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3213 {ECO:0000313|EMBL:SEE83898.1,
RC   ECO:0000313|Proteomes:UP000198754};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-xylose = D-xylulose; Xref=Rhea:RHEA:22816,
CC         ChEBI:CHEBI:17140, ChEBI:CHEBI:53455; EC=5.3.1.5;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00455,
CC         ECO:0000256|RuleBase:RU000609};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00455};
CC       Note=Binds 2 magnesium ions per subunit. {ECO:0000256|HAMAP-
CC       Rule:MF_00455};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|HAMAP-Rule:MF_00455,
CC       ECO:0000256|RuleBase:RU000610}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00455,
CC       ECO:0000256|RuleBase:RU000610}.
CC   -!- SIMILARITY: Belongs to the xylose isomerase family. {ECO:0000256|HAMAP-
CC       Rule:MF_00455, ECO:0000256|RuleBase:RU000609,
CC       ECO:0000256|SAAS:SAAS00580662}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|HAMAP-Rule:MF_00455}.
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DR   EMBL; FNTK01000001; SEE83898.1; -; Genomic_DNA.
DR   Proteomes; UP000198754; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009045; F:xylose isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042732; P:D-xylose metabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00455; Xylose_isom_A; 1.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   InterPro; IPR013022; Xyl_isomerase-like_TIM-brl.
DR   InterPro; IPR013453; XylA_actinobac.
DR   InterPro; IPR001998; Xylose_isomerase.
DR   Pfam; PF01261; AP_endonuc_2; 1.
DR   PRINTS; PR00688; XYLOSISMRASE.
DR   SUPFAM; SSF51658; SSF51658; 1.
DR   TIGRFAMs; TIGR02631; xylA_Arthro; 1.
DR   PROSITE; PS51415; XYLOSE_ISOMERASE; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism {ECO:0000256|HAMAP-Rule:MF_00455,
KW   ECO:0000256|RuleBase:RU000609, ECO:0000256|SAAS:SAAS00472203};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00455};
KW   Isomerase {ECO:0000256|HAMAP-Rule:MF_00455, ECO:0000256|RuleBase:RU000609,
KW   ECO:0000256|SAAS:SAAS00108565, ECO:0000313|EMBL:SEE83898.1};
KW   Magnesium {ECO:0000256|HAMAP-Rule:MF_00455};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_00455,
KW   ECO:0000256|RuleBase:RU000609, ECO:0000256|SAAS:SAAS00472349};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198754};
KW   Xylose metabolism {ECO:0000256|HAMAP-Rule:MF_00455,
KW   ECO:0000256|RuleBase:RU000609}.
FT   DOMAIN          41..265
FT                   /note="AP_endonuc_2"
FT                   /evidence="ECO:0000259|Pfam:PF01261"
FT   ACT_SITE        54
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00455"
FT   ACT_SITE        57
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00455"
FT   METAL           181
FT                   /note="Magnesium 1"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00455"
FT   METAL           217
FT                   /note="Magnesium 1"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00455"
FT   METAL           217
FT                   /note="Magnesium 2"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00455"
FT   METAL           220
FT                   /note="Magnesium 2"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00455"
FT   METAL           245
FT                   /note="Magnesium 1"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00455"
FT   METAL           287
FT                   /note="Magnesium 1"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00455"
SQ   SEQUENCE   388 AA;  43038 MW;  23EACC85CAACA3D3 CRC64;
     MNYQPTPEDR FTFGLWTVGW QGRDPFGDAT RRALDPVETV QRLSELGAHG VTFHDDDLIP
     FGSSDAERES HIKRFREALD ATGMKVPMAT TNLFTHPVFK DGAFTANDRD VRRYALRKTI
     RNIDLAVELG AETYVAWGGR EGAESGAAKD VRVALDRMKE AFDLLGEYVT DQGYSIKFAI
     EPKPNEPRGD ILLPTVGHAL AFIERLERPE LYGVNPEVGH EQMAGLNFPH GIAQALWAGK
     LFHIDLNGQS GIKYDQDLRF GNGDLRAAFW LVDLLESAGY AGPKHFDFKP PRTEDLDGVW
     ASAAGCMRNY LILKERSAAF RADPVVQEAL RASRLDELAQ QTAADGLKAL LADRSAFEDF
     DVEAAAKRGM AFEQLDQLAM DHLLGARG
//
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