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Database: UniProt
Entry: A0A1H5MQW2_9MICO
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ID   A0A1H5MQW2_9MICO        Unreviewed;       364 AA.
AC   A0A1H5MQW2;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   31-JUL-2019, entry version 9.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   ORFNames=SAMN04488554_3512 {ECO:0000313|EMBL:SEE90758.1};
OS   Haloactinobacterium album.
OC   Bacteria; Actinobacteria; Micrococcales; Ruaniaceae;
OC   Haloactinobacterium.
OX   NCBI_TaxID=648782 {ECO:0000313|EMBL:SEE90758.1, ECO:0000313|Proteomes:UP000199220};
RN   [1] {ECO:0000313|EMBL:SEE90758.1, ECO:0000313|Proteomes:UP000199220}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 21368 {ECO:0000313|EMBL:SEE90758.1,
RC   ECO:0000313|Proteomes:UP000199220};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
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DR   EMBL; FNTX01000002; SEE90758.1; -; Genomic_DNA.
DR   BioCyc; GCF_900105765:BLU77_RS17410-MONOMER; -.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000199220; Unassembled WGS sequence.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000199220};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199220};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156}.
FT   DOMAIN       49    346       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
FT   REGION        1     22       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   364 AA;  37897 MW;  6BB3E76AA0E7E850 CRC64;
     MTTTPTAERT DASTGDLRVR RMDPLPTPGE VLAELPLPTA AAELVASARA DAADVLAGAD
     DRLLVMVGPC SVHDPAAAIE YAHRLAGAAE SYADDLVLVM RVYFEKPRTT TGWKGLINDP
     GLDGSYDIPR GLRLARQVLL DVLAAGVPAG CEFLETTSPQ YIADTVSYGA IGARTVESQV
     HRQLASGLSM PVGFKNSSDG DVQVAVDACV AAAAPQAFLG VDTQARAALV ETAGNPDSHV
     ILRGGRRGPN YAPEHVRAAA EKLTAVGRAG VMVDASHGNS GKDHVRQAQV AAEIAEAVAA
     GETAVAGVML ESFLVEGRQE PAPSGLVYGQ SVTDACMSWE VTEGVLEQLA AAARTRRGAL
     RRRA
//
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