ID   A0A1H5MW90_9ACTN        Unreviewed;      1314 AA.
AC   A0A1H5MW90;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=ATP-dependent helicase HrpA {ECO:0000313|EMBL:SEE93612.1};
GN   ORFNames=SAMN05216533_4490 {ECO:0000313|EMBL:SEE93612.1};
OS   Streptomyces sp. Ag109_O5-10.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1855349 {ECO:0000313|EMBL:SEE93612.1, ECO:0000313|Proteomes:UP000198812};
RN   [1] {ECO:0000313|EMBL:SEE93612.1, ECO:0000313|Proteomes:UP000198812}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ag109_O5-10 {ECO:0000313|EMBL:SEE93612.1,
RC   ECO:0000313|Proteomes:UP000198812};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FNTQ01000001; SEE93612.1; -; Genomic_DNA.
DR   STRING; 1855349.SAMN05216533_4490; -.
DR   OrthoDB; 9805617at2; -.
DR   Proteomes; UP000198812; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR   CDD; cd17989; DEXHc_HrpA; 1.
DR   CDD; cd18791; SF2_C_RHA; 1.
DR   Gene3D; 1.20.120.1080; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR048333; HA2_WH.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR024590; HrpA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010222; RNA_helicase_HrpA.
DR   NCBIfam; TIGR01967; DEAH_box_HrpA; 1.
DR   PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR   PANTHER; PTHR18934:SF83; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF11898; DUF3418; 1.
DR   Pfam; PF21010; HA2_C; 1.
DR   Pfam; PF04408; HA2_N; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000313|EMBL:SEE93612.1};
KW   Hydrolase {ECO:0000313|EMBL:SEE93612.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198812}.
FT   DOMAIN          87..251
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          279..446
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
SQ   SEQUENCE   1314 AA;  149574 MW;  3E7DA098AD2126D4 CRC64;
     MSTHPAPALG PLAPRLTELS LRDAHRLGRR LEGARKIRKP EARAAVLAEI EAEVARAEER
     MAARRAVAPA VTYPEQLPVS QKKDEIAEAI RDHQVVIVAG ETGSGKTTQI PKICMELGRG
     VRGMIGHTQP RRIAARTVAE RVAEELRTPL GEAVGWKVRF TDQVNPDATF VKLMTDGILL
     AEIQTDRELR AYDTIIIDEA HERSLNIDFL LGYLAQLLPR RPDLKVVITS ATIDPERFSR
     HFGDAPIIEV SGRTYPVEVR YRPLLEEDAE DADRDQITAI CDAVEELQGE GQGDILVFLS
     GEREIRDTAD ALTRKNYRFT EVLPLYARLS HAEQHRVFQP HTGRRIVLAT NVAETSLTVP
     GIKYVIDPGF ARISRYSHRT KVQRLPIEAI SQASANQRKG RCGRTSDGIC IRLYSEDDFV
     SRPEFTDAEI LRTNLASVIL QMTAAGLGDI EKFPFIDPPD HRNIRDGVQL LQELGAIDPA
     EKDPRRRLTD TGRKLAQLPV DPRLARMVLE ADKNGCVREV MVIAAALSIQ DPRERPAEKQ
     TQADQQHARF RDETSDFLAF LNLWKYVREQ QRERGSSSFR RMCKQEYLNF LRIREWQDIY
     TQLRTVAKQM GIHLNEEDAP GDRVHVSLLA GLLSHIGMKD VKDGAKNEYL GARSAKFALF
     PGSALFKKTP RFVMSAELVE TSRLWARVNA KIEPEWVEPL AEHLLKRTYS EPHWEKDQAA
     VMAFEKVTLY GVPIVADRKV NYGRIDPETS RELFIRNALV EGDWRTHHKF FADNRRLLSE
     VEELEHRARR RDIVVDDDTL FDFYDQRVPE HVVSGAHFDS WWKRKRHEQP EFLDFEREML
     IRESAEAVTK ADYPDSWRQG QLKFRVTYQF EPGADADGVT VHIPLQVLNQ VTDEGFDWQI
     PGLREEVVTE LIRSLPKPIR RNYVPAPNFA KRFLDTAVPL QEPLTTTMAR ELKRMVGVPF
     EAEDFDWAKV PDHLKITFRI VDERRRKLAE DKDLEALKLR LKPKARQALS QAAAATASRE
     GGESLERKGL TDWTIGTLTR VFETRRAGQP VKAYPALVDD GDTVSVRLFD TEEEQAEAMW
     KGTRRLILRN IPVNPAKFAS EKLTNAQKLA LSANPHGTIQ ALFDDCAMAA ADKLIADFGG
     PAWDEESYRK LYDKVRAEIV DTTVRTVGQV QQVLAAWQAC ERRLKAVRSP ALLANLTDVR
     KQLDALVKPG FVTWAGIRRL PDLMRYLVAA DRRLQQMPTN VQRDTTRMEK VHEMQDEYAW
     LLEQLPKGRP VPQQVLDIRW MLEELRVSYF AHALGTAYPV SDKRIVKAID SAAP
//