ID A0A1H5PEP1_9FLAO Unreviewed; 365 AA.
AC A0A1H5PEP1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
GN ORFNames=SAMN04488034_11414 {ECO:0000313|EMBL:SEF12392.1};
OS Salinimicrobium catena.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Salinimicrobium.
OX NCBI_TaxID=390640 {ECO:0000313|EMBL:SEF12392.1, ECO:0000313|Proteomes:UP000199448};
RN [1] {ECO:0000313|EMBL:SEF12392.1, ECO:0000313|Proteomes:UP000199448}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 23553 {ECO:0000313|EMBL:SEF12392.1,
RC ECO:0000313|Proteomes:UP000199448};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IB topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00006645}.
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DR EMBL; FNUG01000014; SEF12392.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H5PEP1; -.
DR STRING; 390640.SAMN04488034_11414; -.
DR OrthoDB; 9778962at2; -.
DR Proteomes; UP000199448; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:InterPro.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR Gene3D; 1.10.132.120; -; 1.
DR Gene3D; 3.30.66.10; DNA topoisomerase I domain; 1.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR035447; DNA_topo_I_N_sf.
DR InterPro; IPR049331; Top1B_N_bact.
DR InterPro; IPR001631; TopoI.
DR InterPro; IPR014711; TopoI_cat_a-hlx-sub_euk.
DR InterPro; IPR013500; TopoI_cat_euk.
DR PANTHER; PTHR10290:SF23; DNA TOPOISOMERASE 1; 1.
DR PANTHER; PTHR10290; DNA TOPOISOMERASE I; 1.
DR Pfam; PF21338; Top1B_N_bact; 1.
DR Pfam; PF01028; Topoisom_I; 1.
DR PRINTS; PR00416; EUTPISMRASEI.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR SUPFAM; SSF55869; DNA topoisomerase I domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:SEF12392.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000199448};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 42..89
FT /note="DNA topoisomerase IB N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21338"
FT DOMAIN 105..315
FT /note="DNA topoisomerase I catalytic core eukaryotic-type"
FT /evidence="ECO:0000259|Pfam:PF01028"
SQ SEQUENCE 365 AA; 42516 MW; D011D7EEAE33E539 CRC64;
MTLSSEEIVK LISNPDLAAE KANLVYISEE DLCIERKKRG RGFQYLKEGE PLDSEEDIKR
IKSLVIPPAW EKVKICPHNT GHLQVVGLDT KGRKQYMYHP DWTRIRNQTK FYKMAAFGKV
LPKVRAQVEK DLKLKGMPRQ KVLALVIRLM EETHIRIGNE AYARENKSYG LSTLRSRHVD
ISSGKMKFNF LGKRGIEHSV SIEDKKLVKL VNQCEEIPGW EVFKYYNESG KKQRIDSGMV
NEYIQEISGE LFSAKDFRTW SATKIFFEHL RETGYVEEEK ENKKIILQAY DVTAEALGNT
RSVCRSYYVH PHVVRLYESG RIVPYFKKVE RKRTSKPQFS QTEEVLLELL KDFDLDLHPS
DPKDH
//
