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Database: UniProt
Entry: A0A1H5RDP3_9PSEU
LinkDB: A0A1H5RDP3_9PSEU
Original site: A0A1H5RDP3_9PSEU 
ID   A0A1H5RDP3_9PSEU        Unreviewed;       827 AA.
AC   A0A1H5RDP3;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE            EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN   ORFNames=SAMN05421837_110247 {ECO:0000313|EMBL:SEF36492.1};
OS   Amycolatopsis pretoriensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Amycolatopsis.
OX   NCBI_TaxID=218821 {ECO:0000313|EMBL:SEF36492.1, ECO:0000313|Proteomes:UP000198878};
RN   [1] {ECO:0000313|EMBL:SEF36492.1, ECO:0000313|Proteomes:UP000198878}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44654 {ECO:0000313|EMBL:SEF36492.1,
RC   ECO:0000313|Proteomes:UP000198878};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC       family. {ECO:0000256|ARBA:ARBA00008263}.
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DR   EMBL; FNUJ01000010; SEF36492.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H5RDP3; -.
DR   STRING; 218821.SAMN05421837_110247; -.
DR   OrthoDB; 9806486at2; -.
DR   Proteomes; UP000198878; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   CDD; cd00187; TOP4c; 1.
DR   Gene3D; 3.30.1360.40; -; 1.
DR   Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR   Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR   Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR   InterPro; IPR006691; GyrA/parC_rep.
DR   InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a_sf.
DR   InterPro; IPR002205; Topo_IIA_dom_A.
DR   PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC/MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 1.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR   SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          26..482
FT                   /note="DNA topoisomerase type IIA"
FT                   /evidence="ECO:0000259|SMART:SM00434"
FT   REGION          805..827
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   827 AA;  89745 MW;  3843F02BE2E16098 CRC64;
     MARRKGTTTK VDPSAFDSPG AHVFDNSLKT EIEDSYLEYA YSVIHSRALP DARDGLKPVH
     RRILYSMNEN GYRPTHAYVK SSRVVGDVMG KYHPHGDVAI YDAMVRLAQD FSLNVPLIDG
     HGNFGSPDDG PAASRYTEAR MSPEAMQLVG ELGEDTVDFR PNYDGSLEEP SVLPAAFPNL
     LVNGTSGIAV GMATNMIPHN LGEVIAAARW LITHPSATLD KLMEFVPGPD LPTGGSLLGL
     DEVRRAYETG RGVVRMRANC ETGPLEGSRG RQAITVTELP YGVGPEKVIE KITDEVNKSK
     RLTGIADVKD LTDRENGTRL VIECKVGVNP QALLADLYRL TPLEQSFGIN NLVLVDGQPQ
     TLGLKELLEV FLRHRYEVVT RRTKYRRRKR EERLHLVDGL LIALLNIDKV IKLIRESENA
     QAAKDGLMTR FKLSEIQATY ILDTPLRRLT KYDRLELESE QERLREEIAE LSKILDDESV
     LKKLVSAELA KIAKDFPTER RTSLIDGDLK EVLAASKPSG PLEVTDDPCQ VILSATGLVA
     RTAAESEEST ETRRRNGRVK HDAVAAVVHT TARGQILLVT SRGRAFKTDV LPLPVLPEQA
     GTVSLRGGMA ARELVPLEKG ETVVGIAPLG EQAAGSPGLA LGTRAGVVKI CSPEWPVRSD
     EFEVISLKDG DEVVGATWLT DGTETLAFMT SEASLLKYAA SLVRPQGLKG GGMAGINVGA
     GTVVFFGAIR TDDDEHGEPL VITSTGASVK VTPFSEYPAK GRATGGVRAQ RFLKGETALR
     VAWIGPRPAG AAKNGDPVEL PEIDVRRDGS GHAHPGPDVV GHLIERD
//
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