ID A0A1H5RDP3_9PSEU Unreviewed; 827 AA.
AC A0A1H5RDP3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN ORFNames=SAMN05421837_110247 {ECO:0000313|EMBL:SEF36492.1};
OS Amycolatopsis pretoriensis.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Amycolatopsis.
OX NCBI_TaxID=218821 {ECO:0000313|EMBL:SEF36492.1, ECO:0000313|Proteomes:UP000198878};
RN [1] {ECO:0000313|EMBL:SEF36492.1, ECO:0000313|Proteomes:UP000198878}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44654 {ECO:0000313|EMBL:SEF36492.1,
RC ECO:0000313|Proteomes:UP000198878};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC family. {ECO:0000256|ARBA:ARBA00008263}.
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DR EMBL; FNUJ01000010; SEF36492.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H5RDP3; -.
DR STRING; 218821.SAMN05421837_110247; -.
DR OrthoDB; 9806486at2; -.
DR Proteomes; UP000198878; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00187; TOP4c; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR006691; GyrA/parC_rep.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC/MITOCHONDRIAL; 1.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR Pfam; PF03989; DNA_gyraseA_C; 1.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 26..482
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
FT REGION 805..827
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 827 AA; 89745 MW; 3843F02BE2E16098 CRC64;
MARRKGTTTK VDPSAFDSPG AHVFDNSLKT EIEDSYLEYA YSVIHSRALP DARDGLKPVH
RRILYSMNEN GYRPTHAYVK SSRVVGDVMG KYHPHGDVAI YDAMVRLAQD FSLNVPLIDG
HGNFGSPDDG PAASRYTEAR MSPEAMQLVG ELGEDTVDFR PNYDGSLEEP SVLPAAFPNL
LVNGTSGIAV GMATNMIPHN LGEVIAAARW LITHPSATLD KLMEFVPGPD LPTGGSLLGL
DEVRRAYETG RGVVRMRANC ETGPLEGSRG RQAITVTELP YGVGPEKVIE KITDEVNKSK
RLTGIADVKD LTDRENGTRL VIECKVGVNP QALLADLYRL TPLEQSFGIN NLVLVDGQPQ
TLGLKELLEV FLRHRYEVVT RRTKYRRRKR EERLHLVDGL LIALLNIDKV IKLIRESENA
QAAKDGLMTR FKLSEIQATY ILDTPLRRLT KYDRLELESE QERLREEIAE LSKILDDESV
LKKLVSAELA KIAKDFPTER RTSLIDGDLK EVLAASKPSG PLEVTDDPCQ VILSATGLVA
RTAAESEEST ETRRRNGRVK HDAVAAVVHT TARGQILLVT SRGRAFKTDV LPLPVLPEQA
GTVSLRGGMA ARELVPLEKG ETVVGIAPLG EQAAGSPGLA LGTRAGVVKI CSPEWPVRSD
EFEVISLKDG DEVVGATWLT DGTETLAFMT SEASLLKYAA SLVRPQGLKG GGMAGINVGA
GTVVFFGAIR TDDDEHGEPL VITSTGASVK VTPFSEYPAK GRATGGVRAQ RFLKGETALR
VAWIGPRPAG AAKNGDPVEL PEIDVRRDGS GHAHPGPDVV GHLIERD
//