ID A0A1H5S393_9RHOB Unreviewed; 318 AA.
AC A0A1H5S393;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0000313|EMBL:SEF44287.1};
GN ORFNames=SAMN05421751_101282 {ECO:0000313|EMBL:SEF44287.1};
OS Jhaorihella thermophila.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Jhaorihella.
OX NCBI_TaxID=488547 {ECO:0000313|EMBL:SEF44287.1, ECO:0000313|Proteomes:UP000236742};
RN [1] {ECO:0000313|EMBL:SEF44287.1, ECO:0000313|Proteomes:UP000236742}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 23413 {ECO:0000313|EMBL:SEF44287.1,
RC ECO:0000313|Proteomes:UP000236742};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FNVD01000001; SEF44287.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H5S393; -.
DR OrthoDB; 9812907at2; -.
DR Proteomes; UP000236742; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:UniProt.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR22981:SF7; 3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR22981; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000236742}.
FT DOMAIN 2..158
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 161..269
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 167
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 318 AA; 33706 MW; 0DD51355FC962413 CRC64;
MRVGFVGLGN VGGKLSGSLL RNGVDLVVHD LNPDLVAAFV ERGAAAGEGP SAMMRDCDAV
ITCLPSPAAS DAVMREMLPE VGPGKIWMEM STTDEAEVKR LGAQVIDRGG AAVDCPVSGG
CHRAATGNIS IFAGCDRETF ERILPLLTKM GRRILHTGPL GSASILKVVT NYLATANLVS
LAEALTVSRA AGMDLNVAYE AIRISSGNSF VHETESQVIL NGSRDISFTM DLVAKDIGLF
QQVADRVGVP LELNPLMIEI FRDGIDRFGP RELSPNIIKR LEEATGLDIR APGFPAKMVD
DEAEAPGAEV IVRRPAAE
//
