ID   A0A1H5SS85_9RHOB        Unreviewed;       732 AA.
AC   A0A1H5SS85;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase {ECO:0000313|EMBL:SEF52657.1};
GN   ORFNames=SAMN04488045_0328 {ECO:0000313|EMBL:SEF52657.1};
OS   Thalassococcus halodurans.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Thalassococcus.
OX   NCBI_TaxID=373675 {ECO:0000313|EMBL:SEF52657.1, ECO:0000313|Proteomes:UP000236752};
RN   [1] {ECO:0000313|EMBL:SEF52657.1, ECO:0000313|Proteomes:UP000236752}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 26915 {ECO:0000313|EMBL:SEF52657.1,
RC   ECO:0000313|Proteomes:UP000236752};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC         NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|ARBA:ARBA00023693};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|ARBA:ARBA00005005}.
CC   -!- SIMILARITY: In the central section; belongs to the 3-hydroxyacyl-CoA
CC       dehydrogenase family. {ECO:0000256|ARBA:ARBA00007005}.
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DR   EMBL; FNUZ01000001; SEF52657.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H5SS85; -.
DR   OrthoDB; 9771883at2; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000236752; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   CDD; cd06558; crotonase-like; 1.
DR   Gene3D; 1.10.1040.50; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43612; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR43612:SF3; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000236752}.
FT   DOMAIN          328..506
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          510..605
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   732 AA;  78090 MW;  607EA35A51234149 CRC64;
     MTEFTMEKGA DGVAVITWDV PGKSMNVLSF DGLRELDAHI DDALADDAVK GVVITSGKDT
     FAAGMDLNVL AKMKEQAGDD PARGLFDGIM QMHGALRKIE RAGMDAKTNK GGKPIAAALP
     GTALGIGLEI PLACHRIFCV PDPKAKIGLP EIMIGIFPGA GGTTRMVRKM GAMAASPFLL
     EGKLSDPIKA KAAGIIDEVV ADPVAEAKEW VLNAGDKDIV KPWDEKGYKM PGGAPYHPAG
     FMTFVGASAM VNGKTKGVYP AAKALLSAVY EGAMVPFDTA LKIEARWFVN VLMNPSSSAM
     IRSLFINKGA LEKGAVRPAD VADQSVKKVG VLGAGMMGAG IALVSALAGI EVVLIDQKQE
     AADKGKAYSE TYLDKGIKRK KITEDKKEKV LGLINATTDY AALEGADLII EAVFEDPAIK
     AEVTAKVEAV IGEDCIFATN TSTLPISDLA KASKRPEQFI GIHFFSPVEK MMLVEIIKGK
     ETGDRAVAKA LDYVRQIKKT PIVVNDARFF YANRCIIPYI NEGIRMVAEG INPALIENAA
     KLVGMPLGPL QLVDETSIDL GAKIARATKA AMGDAYPDAA VDDVIFWMEG EGRLGRKANA
     GFYAYDEKGK RVGLWGGLEA KYPVADDQPD LTEVQHRLLF AQSLEAVRAL EEGVLMDIRE
     GDVGAILGWG FAPWSGGPLS WLDIIGAPYA AERCDQLEAK HGARFACPPL LREMADKGQS
     FYGRFSPEAD AA
//