ID   A0A1H5V8Y4_9FIRM        Unreviewed;       642 AA.
AC   A0A1H5V8Y4;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=Ech hydrogenase subunit A {ECO:0000313|EMBL:SEF83842.1};
GN   ORFNames=SAMN05216537_11047 {ECO:0000313|EMBL:SEF83842.1};
OS   Lachnospira multipara.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC   Lachnospira.
OX   NCBI_TaxID=28051 {ECO:0000313|EMBL:SEF83842.1, ECO:0000313|Proteomes:UP000236726};
RN   [1] {ECO:0000313|EMBL:SEF83842.1, ECO:0000313|Proteomes:UP000236726}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D15d {ECO:0000313|EMBL:SEF83842.1,
RC   ECO:0000313|Proteomes:UP000236726};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU000320}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU000320}.
CC   -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit A
CC       family. {ECO:0000256|ARBA:ARBA00008483}.
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DR   EMBL; FNUL01000010; SEF83842.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H5V8Y4; -.
DR   STRING; 1410661.GCA_000702205_01938; -.
DR   Proteomes; UP000236726; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   InterPro; IPR001516; Proton_antipo_N.
DR   PANTHER; PTHR43373:SF1; ANTIPORTER SUBUNIT MNHA2-RELATED; 1.
DR   PANTHER; PTHR43373; NA(+)/H(+) ANTIPORTER SUBUNIT; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   Pfam; PF00662; Proton_antipo_N; 1.
DR   PRINTS; PR01434; NADHDHGNASE5.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000236726};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000320};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        30..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        66..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        91..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        122..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        166..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        190..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        253..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        286..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        328..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        353..372
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        378..395
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        416..437
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        457..475
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        502..522
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        542..566
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        623..641
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          121..152
FT                   /note="NADH-Ubiquinone oxidoreductase (complex I) chain 5
FT                   N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00662"
FT   DOMAIN          185..469
FT                   /note="NADH:quinone oxidoreductase/Mrp antiporter membrane
FT                   subunit"
FT                   /evidence="ECO:0000259|Pfam:PF00361"
SQ   SEQUENCE   642 AA;  71059 MW;  F4B680D012D25317 CRC64;
     MAIIPFLIIF PLVIAIIMYC TRINKIRNAI AYLSAVVIMV SVGVLVCQWI SKGMETITLY
     YNTELVDHII LAAEIVLMGV VTYLSFKYKK AWVSLLSICP TALIAYYEIF GPETREVVGH
     IYIDYLSILM CIIVGIIGSL IVVYAVGYMH GYHHSAHHSN VTDRRYYFFA LLFLFLGAMF
     GFVLSENLLW IDFFWEMTSI CSFLLIGYTR EEEAVNNSFR ALWMNLLGGC ALAIAIVYFG
     YTYENVDLHT LVAMGTIQSK CAVICVALIA FAALTKAAQL PFSTWLIGAM VAPTPSSALL
     HSATMVKAGI YVLLRLAPAM SGTLTGEMIA FVGGFTFLIT SFMAIAQSDG KKVLAFSTIS
     NLGLMVACAG VGTSETVWAA IFLMMFHAIS KSLLFQDIGA TENALGSRDV EDMHGLLYML
     PKLAIFMFIG IAGMFLAPFG MLISKWAALK ASVDVRNIVL VFFIIFGSAT TSFYWTKWMG
     KIISHGHLNG NPVKDKTKKN EMISLTIHAI LMIALCALFP LVSETFVNPL VNEMFGKSEN
     VLSNQVLFTL IIIIVVVFAV PFLAYLSSKQ QTQDLKLSYM NGVNTGDNRA FTDSLGNEKT
     LWLSNFYFHK IIGSRKLMMP SQIFTLAVIV VMMCRIIGGV FL
//