ID A0A1H5WBW0_9ACTN Unreviewed; 524 AA.
AC A0A1H5WBW0;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Signal transduction histidine kinase {ECO:0000313|EMBL:SEF96945.1};
GN ORFNames=SAMN04489712_102660 {ECO:0000313|EMBL:SEF96945.1};
OS Thermomonospora echinospora.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Thermomonosporaceae; Thermomonospora.
OX NCBI_TaxID=1992 {ECO:0000313|EMBL:SEF96945.1, ECO:0000313|Proteomes:UP000236723};
RN [1] {ECO:0000313|Proteomes:UP000236723}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43163 {ECO:0000313|Proteomes:UP000236723};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FNVO01000002; SEF96945.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H5WBW0; -.
DR OrthoDB; 3288457at2; -.
DR Proteomes; UP000236723; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd16917; HATPase_UhpB-NarQ-NarX-like; 1.
DR Gene3D; 1.20.5.1930; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR PANTHER; PTHR24421; NITRATE/NITRITE SENSOR PROTEIN NARX-RELATED; 1.
DR PANTHER; PTHR24421:SF10; SENSORY TRANSDUCTION HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF07730; HisKA_3; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:SEF96945.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000236723};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 27..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 117..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 172..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 289..354
FT /note="Signal transduction histidine kinase subgroup 3
FT dimerisation and phosphoacceptor"
FT /evidence="ECO:0000259|Pfam:PF07730"
FT DOMAIN 401..494
FT /note="Histidine kinase/HSP90-like ATPase"
FT /evidence="ECO:0000259|Pfam:PF02518"
FT REGION 492..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..509
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 524 AA; 55811 MW; 8261FD09A9FCC157 CRC64;
MTSDNSDSRP PFGQEIAQYA WRLSGRLVAG LGQLLLWIIT GLGRLLRPLV LRAGAGLFGM
FRRGTGRQAP APGHPGMPYP GPGSDGRTRI VPGGPAAMAQ TAPMPRWVGF WREFAGSWYY
APLTGAALVV AALAELAPQG VPPVSVAGGF AVAATLPLVW RREFLRPVAA VVLSAFAAGL
LSGQPLLFTT AFAALYTLYE LGRHLPRQSA GALAVGASAT VGVVYLAAET LDDIPWPAAL
VAVLAAIGLG DARRVVESAE RTEAEAAERT SETLTRLTAV QREQAVMRER ARIARELHDV
VAHSVSMIAV QAETAPYTMD DLSPQAREGY LEIARTAREA LVEMRRLLGV LRADAGTGPP
ESAPQPRLDR LPELIEQHRG AGGQAELQVR GDPRALSTTV ELSAYRIVQE ALTNARRHAP
GAEVQVELAY LNDRLAVRVR DTGANAPTMV LDPSEAGGHG LVGMRERATM LGGRFSAGPA
SEGGFMVEAE LPFAREETPR SDAHPAHPAR SARSARSPGR HDRR
//
