ID A0A1H5WC09_9SPHI Unreviewed; 1524 AA.
AC A0A1H5WC09;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Hydrophobic/amphiphilic exporter-1, HAE1 family {ECO:0000313|EMBL:SEF96920.1};
GN ORFNames=SAMN05421877_1042 {ECO:0000313|EMBL:SEF96920.1};
OS Sphingobacterium lactis.
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Sphingobacterium.
OX NCBI_TaxID=797291 {ECO:0000313|EMBL:SEF96920.1, ECO:0000313|Proteomes:UP000236731};
RN [1] {ECO:0000313|Proteomes:UP000236731}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22361 {ECO:0000313|Proteomes:UP000236731};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Cell membrane
CC {ECO:0000256|RuleBase:RU362097}; Lipid-anchor
CC {ECO:0000256|RuleBase:RU362097}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the outer membrane factor (OMF) (TC 1.B.17)
CC family. {ECO:0000256|ARBA:ARBA00007613, ECO:0000256|RuleBase:RU362097}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942}.
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DR EMBL; FNUT01000004; SEF96920.1; -; Genomic_DNA.
DR OrthoDB; 9758234at2; -.
DR Proteomes; UP000236731; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042908; P:xenobiotic transport; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR Gene3D; 1.20.1600.10; Outer membrane efflux proteins (OEP); 1.
DR Gene3D; 2.20.200.10; Outer membrane efflux proteins (OEP); 1.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004764; MdtF-like.
DR InterPro; IPR003423; OMP_efflux.
DR InterPro; IPR010131; RND_efflux_OM_lipoprot_NodT.
DR NCBIfam; TIGR00915; 2A0602; 1.
DR NCBIfam; TIGR01845; outer_NodT; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF9; SIMILAR TO MULTIDRUG RESISTANCE PROTEIN MEXB; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR Pfam; PF02321; OEP; 2.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR SUPFAM; SSF56954; Outer membrane efflux proteins (OEP); 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipoprotein {ECO:0000256|RuleBase:RU362097};
KW Membrane {ECO:0000256|RuleBase:RU362097, ECO:0000256|SAM:Phobius};
KW Palmitate {ECO:0000256|RuleBase:RU362097};
KW Transmembrane {ECO:0000256|RuleBase:RU362097, ECO:0000256|SAM:Phobius};
KW Transmembrane beta strand {ECO:0000256|RuleBase:RU362097};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 394..419
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 440..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 472..499
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 542..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 872..888
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 895..919
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 925..950
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 971..990
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1002..1029
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1041..1058
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT COILED 1237..1309
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1524 AA; 167860 MW; F7975FDF4BF3F86D CRC64;
MFEKFIKRPV LSLVISIFIT LLGLLALFTL PITQFPDIVP PSVVVTANYT GANAEVSTNA
VAIPLEKAIN GVAGMTYMSS VSTNNGNTLI QVFFEVGTDP DIAAVNVQNR VTTVLDELPE
EVIKAGVTTE KEVNSMLMYL NLYTDDETAD ERFIYNFTDI NILKELKRIE GVGFAQIMGM
KDYAMRIWVK PDRLSAYSIS TEELVTALRR QNIEAAPGQT GISSDKTVNM QQYVLRYPGK
FTEISEYENI PIRANVDGSI IRVKDIADVE FGSLDYEMVS KTDGRPSASI MIKQLPGSNA
QEVIQRVKDR MAELKEATFP PGMTYTMGYD VSRFLNASIS SVLITLVEAF ILVFLVVFIF
LQDFRATIIP ILAVPVCLIG SLFFMQMMGF SINLLTLFAL VLAIGIVVDN GIVVVEAVYA
KMEEEHLSPM EATLAAMSEV GSAVIAITLV MSAVFVPVAF LSGPVGIFYR QFSLTLAAAI
VISGINALTL TPALCAIILR SPHDKKPGNG LLDRFFRGFN KVYDKISGNY KGLLSKIAGR
RIITLLGLVI MFVATWGSAA ILPGGFIPTE DQGMIYVAVT TPPGATVDRT EAVLNEVDEI
SRSLDVVETV SILAGYSIVT EVSGASYGMG MINLKAWEDR DQSIDDVMTI LREKTSHIAD
AEIEFFPPPT VPGFGNSSGF ELRLLDRSGN EDLNQTNEVV NDFIAKLQED EVIESASTTF
DVNFPQYMLK IDYDLAAKKG ISVENSMNTL QTLLGSLYAT NFIRYGQMYK VMVQSDAFSR
QRPEDVLNLY VKTEEGEMVP YSSFMTMERI YGPEQITRYN MFTSAMITGQ AAPGFSSGQA
IDAVERIAAE LPQGYTIEWS GMTREQKISG NQAAYIFLLC LVFVYLLLAA QYESFLLPMP
VILCLPAGLF GAFLFLKVFG LENNIYAQVS LVMLIGLLGK NAILIVEYAN LKRKQGMDVL
TASIEGAVAR LRPILMTSFA FAAGLIPLML ANGAGAIGNR TIGSAAVGGM VIGTIIGVIV
IPGLVVLFSK RDKKDKVKKR KRVAEAVVAG AVLLFIASCS VPKTTTEKQV STDITGAAKG
IMQDSVTLGT LPWNEVFTDP HLKGLIDSAL LNNLDVRQAF HRIEMAQANF KFRKSALYPS
VDAAVEGGLR KYGHYTESGI GNYDSNFSEN LTDDEKLPEP FIPDYFVGVR ASWELDLWGK
LRNRRESAFL QLMSQSEFKR LIETELIASI ASSYYELLSL DEKIKVYEEN ITLHERALEI
IEAQKDAGRA DELAVQQFKS ILAESKANRE LAEQEILNYE HQINSLLGRV YQPIARNSAP
IGGNMLFQDL SVGRVEDLLN NRLDIRQAGM ELKADFHELE SSRLAFLPTV AISPYLGLQS
FSFDKLFTLD KSVTYGLFGG ITMPIFRQRE LRSEYEIMKA TYGISFLEYE KVVLNAVNEV
SLALNTQDAI AKREVHVKDQ VAALEASIVA AEELFIAGRI TYLDIITAQK GLIAAQVADV
DVNKEKMLNQ VVLYKALGGG WKAM
//
