ID A0A1H5WE92_9ACTN Unreviewed; 2726 AA.
AC A0A1H5WE92;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Amino acid adenylation domain-containing protein {ECO:0000313|EMBL:SEF97795.1};
GN ORFNames=SAMN05444920_1011158 {ECO:0000313|EMBL:SEF97795.1};
OS Nonomuraea solani.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Streptosporangiaceae; Nonomuraea.
OX NCBI_TaxID=1144553 {ECO:0000313|EMBL:SEF97795.1, ECO:0000313|Proteomes:UP000236732};
RN [1] {ECO:0000313|EMBL:SEF97795.1, ECO:0000313|Proteomes:UP000236732}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.7037 {ECO:0000313|EMBL:SEF97795.1,
RC ECO:0000313|Proteomes:UP000236732};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FNVT01000001; SEF97795.1; -; Genomic_DNA.
DR OrthoDB; 2472181at2; -.
DR Proteomes; UP000236732; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 2.
DR CDD; cd19531; LCL_NRPS-like; 2.
DR CDD; cd06173; MFS_MefA_like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR020802; PKS_thioesterase.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF07690; MFS_1; 1.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SMART; SM00824; PKS_TE; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000236732};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2339..2357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2435..2456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2462..2481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2512..2540
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2546..2567
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2574..2594
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2600..2622
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2634..2651
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2671..2691
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 935..1010
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1960..2043
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2726 AA; 289409 MW; F8E6EA2978D1AB5C CRC64;
MTEVRPDRIA ELLRSRFAVA QAAAESSGSA GIPALSTTDM PLSPAQERLW FLAQLEPESA
AYNVPLALRL SGPVDVAALT GAVSDLAERH WILRGVIEDG RVRPAGRVPV SVVDVDPAEL
ERELSERAWR PFRLDAEPPM RATVFRLGGD ECVLALTLHH IATDAWSEGL LLRDLSALYA
ARLGLTPPPE PPALQYADVA AWEAGRPETG LDWWTERLAG LPPVLDLPAT HPRPAVSTWQ
GASVRVEVPE ALSAKVRAAA GATPFMVFLA GLQALLARLS GGDDIAVGVP HAGRHHPDAE
EVVGCFINTL VMRTDTSGDP TGAELLGRAR ATALDAFTHA ATPFERIVER LQPERNLSVT
PLFQVMLNVY DAGPPVNLPG VGVRAEPLPS PTAKFDLNLQ LGDDGTRFSG ELRYRTDLFD
EPAARQLVDW YVALLDAMLT EPDQPVRLPT GADLRGPALE WAAGVPLHGY FERIADTVPD
ALAVFASSGD GLSYAELERR ANQVAHWLLA QGVRPQEPVG VLMERRPELA VALLGVLKAG
AAYLPLDPIY PARRTESVVA TAGVRIVLTE AEIADTADQS GDRPDVPVPP DHLAYVIYTS
GSTGEPKGVA VEHRQITHYL GAIADHLPGD LASFALVSTT AADLGLTNVL WPLTTGATLH
LIDHETATDP DAYAAHQAAH PVDAVKMVPS QLELLGMTAL PGKLLVLAGE AVTADLVERV
RAARPDLAVK IYYGPSETTI TALACDAAEV RPGLAPLGRP LANVVCRVVD GAGRPLPHGV
PGELWIGGPG VARGYLNRPG LTAERFTDGW YRTGDRVRIG PGGLVEFLGR VDDQVKVRGF
RVELGEVTAA LRALPQVAEA FVQPVGDGAL RRLAAWVTPD GLDAAAIRAA LRERLPDYMV
PAAIGSLKTF PLTPNGKVDR AALPLPEAAP AARAPLSTPA ECLVAEVWAE VLELPRVWAD
DDFFVLGGHS FAATRVTGRL RERLGAPVPV RLLFEHPVLA DLAAALPRPS SAATVRRERA
DGPAPLSGTQ ARLWFLAQLE PESAAYNVPV ALRLNGPLDA EALLGAVRDL AERHHVLRGV
IDDSGPEPVL VTRPVSDVPI VTRTVEPSGV AAALDEQLAT PFALDREPPM RAVLFAVGER
EHVLSITFHH IATDAWTKGL LLSELSALYA ARLGLRESPE PPPAQYAEVA PLPDLAELDW
WAERLRGLPP VLDLPADRPR PAVADPGGGE VELAIPAELS ERVRAVAAAY RATPFIVLLA
GLQALLARLS ASTDIAVGVP VAGRDRPETE GVAGCFLNTV VVRTDTGADP TGRDLLTRVR
EDALGAFAHA DAPFDRVVDR LRPERNLAAT PLFQVMLNYY PDPGRPELPG LDVSELHLEE
QTAKFDLNWY VIDAGPDSPL RGGLGYRTDL FEPDTAARFT RWYLALLDGM LADLDTPVGA
VPLEPVTGPV ITGSVLPPAP GDSVHRLIEH WVDETPDAPA VVGADRGLTY AELEESANRI
AHWLLDNGVR ANEPVGVLLE PGAGLACALF GIQKSGGGYL PMDPAYPAAR IAAMLDAAEV
RTVVTTAEFA GLIARDRRVL TLDRLPSLAS TRPSVDVRPE HLHHVIFTSG STGTPKAVAA
EHGGVMNYLS GMLPRIGVPG GSYAVVSTPA ADFGLTCVFG ALTTGGTVHL VPRETAMDPA
AFAEYLTEHR VDVVKCVPSH LELLASGGDL PSVLPDKLLI LAGEACPWDL VERARAARPG
LRIQSHYGHT ESTMICLVCD TEEIPAARRT GIVPLGRPLP GVYGHLVDAS LRPVPPGVPG
ELVVGGSGVT RGYIGLPELT AERFVPDPLT GQGRCYRSGD LLRLTSDGQI EFRGRVDDQV
KVRGYRVELG EVVTALRALP QIAEAVVLPV GEGKARQLAA WVTPATVEAA VVRSSLRERL
PDYMVPAHIV ALDRLPLNPN GKVDRAALPE PQPEQAKYVA PATANEELVA RAWAQVLGVP
EVGAGDDFFA LGGDSFAAVR AVKEIGRGLR VIDLFTRPTV AELAAFLDRE DGGGLLHRLG
GGRTSEFTLV CIPYGGGSAA VYQPLAWALG DRVEVLSVEL PGHDPARPDE PPLPLDELVA
RLAPEVAAAA SGPVAIYGHC VGSAPALALA RRLEADGVEV AGVIAAGSFP AARLPGLAQR
LFRGDRWVSD RMFHDALRAT GGLLDDMDEA AKQASVRAMR HDATEARDWF GRELAAGGAP
LRAPILCVVG ERDRITELYQ ERYAEWAVFG SRVDLAVLPR AGHYFLRHQA EPLAALVMEH
LRRWAAGDLP APVPPPERTG LRPFYTVATG QLVSTVGSAL SSFALGVWAF QHSGKILDLA
LVVMLSQIPA VLLTPLGGAL ADRVDRRRIM LACDAVSGLA MAAMVLLLVT GGLDLLSVCL
IVGVTSVVTA FQQPAYLAAI AQLVPKPYLP QANALANLGF GIGNVVAPLA GGALIGTLGL
SAVVAIDVIT FGVGVVTLLA VRFPDRLFRK QEETFRAALT GGWHFLRRRR PLLVMALYFA
VVNFGTALMW VLITPVVLGL GTSGDLGLVT ALGGLGAAAG TGLVLVWGGT RRRATGMVGF
VIGSGLSMIL MGAWPALGLV AAGLFFRLAC MSITNAHWLS IIQVKVGQEL QGRVLAVNVM
LATAMQPLGF LSAGPLADWA QPYTSGGAGR GAALVLLVSG VLLVVWAVLG LRYRTLHYLE
DLVPDAAPPP EAAADLNAVQ ERVLAA
//