ID A0A1H5XB72_9FIRM Unreviewed; 820 AA.
AC A0A1H5XB72;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Competence protein ComEC {ECO:0000313|EMBL:SEG08690.1};
GN ORFNames=SAMN05216537_1256 {ECO:0000313|EMBL:SEG08690.1};
OS Lachnospira multipara.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Lachnospira.
OX NCBI_TaxID=28051 {ECO:0000313|EMBL:SEG08690.1, ECO:0000313|Proteomes:UP000236726};
RN [1] {ECO:0000313|EMBL:SEG08690.1, ECO:0000313|Proteomes:UP000236726}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=D15d {ECO:0000313|EMBL:SEG08690.1,
RC ECO:0000313|Proteomes:UP000236726};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FNUL01000025; SEG08690.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H5XB72; -.
DR Proteomes; UP000236726; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR004797; Competence_ComEC/Rec2.
DR InterPro; IPR025405; DUF4131.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF13567; DUF4131; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000236726};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 49..67
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 254..276
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 282..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 352..370
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 422..442
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 449..469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 498..514
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 526..546
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 561..772
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 820 AA; 92435 MW; 302BF6BF71EE7C68 CRC64;
MERPIFIAAI FALITAFTSI FLGQELTIFV LITGLLILLA LREYKKVSYL YLIILLIIPI
VSIRSYFYKN QAKLISNLEV KEELNTNVSG YVTCITKTEN GISFRLMNVR VEVDKDVYHA
DDHASDYGSE KTVSEKFSIL VYAEANTDLL EGDYIEASGK LKRLNTSRNE GNYNQEEYYK
SLGIRASFTI SDLKKIDKSK TGIYPELFRL KGNLIRVYDK IFTKDKAAIV KAMTLGVRTD
LTEQQKLDFK DSGIAHLLSI SALHVSLLGL TIYKLLKRKL DYLVAAIIAV FIMLSYLIIT
NNGISCRRAV IMLIAYCIAD NLARSNDLIT TISLSLIILI VDDPYVITNT GFLLSFLSMA
AIAFIYPIVI NDEKILMLFK REELNKKDMK QKIKRKLSEA FCLSLSIQIA TLPVIILMNY
EVALLSVLLN LIVIPLFSLL MVSAFLSGII GLFNIFLALL FAGSSNYILD FYSLLMKIST
SFKGSIILTG APRREFVIAY YLILLVIIIL AKLLRDEILF KYVSFFQKTL FGAYIFLIII
GLNLHYKELS GLNIVSLDVG QGDCQLVSLE GKNFLIDGGS TDVKNVGEYR IYPSLKYRGI
KSLEAITVSH FDSDHVNGLI ELLEKADRLE IKKIVIPDVE KLEENENYLK MIKLAKERGI
KLEYIKAGDV LYFQKNKGFK ITCLHPLKNF NYEDANDYST SFLINYGDFK ALTIGDATAL
AEKAIMDNAM AFGVDISNIN LLKVGHHGSK TSSSKEFIDF TKPSFSIISC GIKNRYHHPN
EETLDKLNAI NSKIYITSKI GEIMINTKNS GKLTIRGYLD
//
