ID A0A1H5Y349_9RHOO Unreviewed; 953 AA.
AC A0A1H5Y349;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Multisubunit potassium/proton antiporter, PhaA subunit /multisubunit potassium/proton antiporter, PhaB subunit {ECO:0000313|EMBL:SEG18343.1};
DE SubName: Full=Na(+) H(+) antiporter subunit AB {ECO:0000313|EMBL:APR03662.1};
GN ORFNames=SAMN05216242_12320 {ECO:0000313|EMBL:SEG18343.1}, Tchl_0798
GN {ECO:0000313|EMBL:APR03662.1};
OS Thauera chlorobenzoica.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Rhodocyclales; Zoogloeaceae;
OC Thauera.
OX NCBI_TaxID=96773 {ECO:0000313|EMBL:APR03662.1, ECO:0000313|Proteomes:UP000185739};
RN [1] {ECO:0000313|EMBL:SEG18343.1, ECO:0000313|Proteomes:UP000236741}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3CB-1 {ECO:0000313|EMBL:SEG18343.1,
RC ECO:0000313|Proteomes:UP000236741};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:APR03662.1, ECO:0000313|Proteomes:UP000185739}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3CB1 {ECO:0000313|EMBL:APR03662.1,
RC ECO:0000313|Proteomes:UP000185739};
RA Goris T., Mergelsberg M., Boll M.;
RT "Complete genome sequence of Thauera chlorobenzoica, a Betaproteobacterium
RT degrading haloaromatics anaerobically to CO2 and halides.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU000320}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU000320}.
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DR EMBL; CP018839; APR03662.1; -; Genomic_DNA.
DR EMBL; FNVJ01000023; SEG18343.1; -; Genomic_DNA.
DR RefSeq; WP_075147252.1; NZ_FNVJ01000023.1.
DR AlphaFoldDB; A0A1H5Y349; -.
DR STRING; 96773.Tchl_0798; -.
DR KEGG; tcl:Tchl_0798; -.
DR OrthoDB; 9811798at2; -.
DR Proteomes; UP000185739; Chromosome.
DR Proteomes; UP000236741; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR007182; MnhB.
DR InterPro; IPR025383; MrpA_C/MbhD.
DR InterPro; IPR046806; MrpA_C/MbhE.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR43373:SF1; ANTIPORTER SUBUNIT MNHA2-RELATED; 1.
DR PANTHER; PTHR43373; NA(+)/H(+) ANTIPORTER SUBUNIT; 1.
DR Pfam; PF13244; MbhD; 1.
DR Pfam; PF20501; MbhE; 1.
DR Pfam; PF04039; MnhB; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR PRINTS; PR01434; NADHDHGNASE5.
PE 4: Predicted;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000320};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 72..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 107..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 162..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 205..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 242..264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 402..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 450..469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 501..522
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 568..586
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 598..619
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 624..644
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 650..671
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 692..710
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 751..771
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 792..814
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 826..848
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 855..876
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 896..920
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 65..110
FT /note="NADH-Ubiquinone oxidoreductase (complex I) chain 5
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00662"
FT DOMAIN 126..403
FT /note="NADH:quinone oxidoreductase/Mrp antiporter membrane
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF00361"
FT DOMAIN 609..673
FT /note="MrpA C-terminal/MbhD"
FT /evidence="ECO:0000259|Pfam:PF13244"
FT DOMAIN 687..765
FT /note="MrpA C-terminal/MbhE"
FT /evidence="ECO:0000259|Pfam:PF20501"
FT DOMAIN 794..917
FT /note="Na+/H+ antiporter MnhB subunit-related protein"
FT /evidence="ECO:0000259|Pfam:PF04039"
SQ SEQUENCE 953 AA; 100080 MW; F312690A69F82AEE CRC64;
MNLVLVVLLP FIGALLPALM IRAGRNACAT ATFAFTLLAF ALLLSHAPAV FRGEVVHAGW
SWLPALGLEA NFFLDGLGFF FAGLILGIGL LIIVYARFYL AKDDPMGTFY SYLLLFQGAM
VGIVLSDNIL LLLVFWELTS LSSFLLIGYW KHLPEGRQGA RMALTVTGAG GLAMIAGMLM
LGEIAGSYNL TDILQQKEAI QASPLYLPAL LLILGGCFTK SAQFPFHFWL PHAMAAPTPV
SAYLHSATMV KAGLFLLARM WPVLAGTAEW FYLVATTGLL TMLIGAFIAL FKDDLKGLLA
YSTVSHLGLV TMLFGFGTPL AAVAGVFHIL NHATFKAALF MNAGIVDHEA GTRDIRRLGG
LLQLMPVSAT LALVAAASMA GLPPLNGFLS KEMMLHEAAA TAWLGNGWGV AALATLAACF
SVAYSLRYIV HVFFGPKRDD YPHPPHDPPA GMWLPPALLV ALVVLIGLFP ETLAGPLVAV
VSGAVTGGAA PDYQLALWHG FTPALGLSAI ALAVGGGALV AYPRLRALWQ AGAHPEAKAI
FDGVLAAAVA GSRRLIHGVH NGSQQRSVAF LVGAVTAAGF AAFSAAPHGA GTRALLPAVP
VAVVAWVLLL GGCALALLLY RKRLLAVVAV GAVGLIVCVA FLYLSAPDLA LTQISVEVAT
VILILLALYF LPKEGPLSSS IERQPLRHLR DGVLAGAAGL GMALASWAML TRDGSSLSGY
YLENAVSGGG GTNVVNVILV DFRGFDTFGE ITVLGIAALA IYALLDGALH GRVGRRLSAW
TPDLPVSVDR HPMIMVVATR VMLPLALLVG AYIFLRGHNQ PGGGFIAALV VSIALIMQYM
ASGFGWAAQR VKVDYHALIG AGVLIAAVTG IGAMVLDQPF LTSTFGHFHL PLVGEFELAS
AMAFDTGVFL TVVGAVMLAL ANLSRMGRRA GHLPVNKAPM DIDPSAVPPQ EQN
//
