ID A0A1H5YIK7_9ACTN Unreviewed; 664 AA.
AC A0A1H5YIK7;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=prolyl oligopeptidase {ECO:0000256|ARBA:ARBA00011897};
DE EC=3.4.21.26 {ECO:0000256|ARBA:ARBA00011897};
GN ORFNames=SAMN05444920_102305 {ECO:0000313|EMBL:SEG23824.1};
OS Nonomuraea solani.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Streptosporangiaceae; Nonomuraea.
OX NCBI_TaxID=1144553 {ECO:0000313|EMBL:SEG23824.1, ECO:0000313|Proteomes:UP000236732};
RN [1] {ECO:0000313|EMBL:SEG23824.1, ECO:0000313|Proteomes:UP000236732}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.7037 {ECO:0000313|EMBL:SEG23824.1,
RC ECO:0000313|Proteomes:UP000236732};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.;
CC EC=3.4.21.26; Evidence={ECO:0000256|ARBA:ARBA00001070};
CC -!- SIMILARITY: Belongs to the peptidase S9A family.
CC {ECO:0000256|ARBA:ARBA00005228}.
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DR EMBL; FNVT01000002; SEG23824.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H5YIK7; -.
DR OrthoDB; 9801421at2; -.
DR Proteomes; UP000236732; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.130.10.120; Prolyl oligopeptidase, N-terminal domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002471; Pept_S9_AS.
DR InterPro; IPR023302; Pept_S9A_N.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002470; Peptidase_S9A.
DR PANTHER; PTHR42881; PROLYL ENDOPEPTIDASE; 1.
DR PANTHER; PTHR42881:SF2; PROLYL ENDOPEPTIDASE; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR Pfam; PF02897; Peptidase_S9_N; 1.
DR PRINTS; PR00862; PROLIGOPTASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF50993; Peptidase/esterase 'gauge' domain; 1.
DR PROSITE; PS00708; PRO_ENDOPEP_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000236732}.
FT DOMAIN 10..389
FT /note="Peptidase S9A N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02897"
FT DOMAIN 453..658
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
SQ SEQUENCE 664 AA; 72137 MW; D5A4C6A20C1CF198 CRC64;
MKFPDNYPPA ERLPLIDRRH GHDVEDPYRW LEDPADPRTE TWLKAQDRLW QDGAARLPGR
ERFLARLTEL RDTGLVTAPV WRGEKRFHLR QSTSQEHPVL YCDDRVVLDP MELDPTGLTT
LDDWQPDLEG RRLAYQISRS GDEKACLYVR ELGTGTVIDG PIGGCRYSAV AWLPGGEAFY
YVRFQQGVHL HRIGDPDDIP IFTRGRISYG VQISPDGRWL TISAGGPSGN SLWLADLAHG
DPAEPRPRPV QEGAHARTAG AVACDGRLYL LTDRDAPRRR LCVADPEAPT AWRELIPEDR
EAVLGAFTLL DGDRLLVSRT RHAVGEIAVH HARTGERLGT VPLPGSGSIA SLTSRPDGGP
EAWFAYTDAV TPAEIWRYDA RSDTTTLWSS APGRVSLPAV DSHHIEYASA DGTPIRMVVV
AKPGQDGPRP TILSGYGGFG IPLMPGYAAD SLAWVEAGGV LAIANLRGGG EEGEGWHRDG
MLDRKQNVFD DFVAAAEKLI ADGWTAPGRL GIWGESNGGL LVGAVLTQRP DLFAAAVCSA
GLLDMARYHL SGLGPAWTGE YGDPDDAEQL GWLLGYSPYH HVERGVDYPA TLFTVSAADT
RVDPMHARKM CAALQWATAG DRPVLLRHEP DVGHGARAVS RSVGLAADVL AFLAAHTGPG
SDPA
//
