ID A0A1H5Z5L4_9RHOB Unreviewed; 406 AA.
AC A0A1H5Z5L4;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=23S rRNA m(5)U-1939 methyltransferase {ECO:0000313|EMBL:SEG30626.1};
GN ORFNames=SAMN04488045_2390 {ECO:0000313|EMBL:SEG30626.1};
OS Thalassococcus halodurans.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Thalassococcus.
OX NCBI_TaxID=373675 {ECO:0000313|EMBL:SEG30626.1, ECO:0000313|Proteomes:UP000236752};
RN [1] {ECO:0000313|EMBL:SEG30626.1, ECO:0000313|Proteomes:UP000236752}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 26915 {ECO:0000313|EMBL:SEG30626.1,
RC ECO:0000313|Proteomes:UP000236752};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RNA M5U methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01024}.
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DR EMBL; FNUZ01000003; SEG30626.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H5Z5L4; -.
DR OrthoDB; 9804590at2; -.
DR Proteomes; UP000236752; Unassembled WGS sequence.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 2.40.50.1070; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR030382; MeTrfase_TRM5/TYW2.
DR InterPro; IPR030390; MeTrfase_TrmA_AS.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR010280; U5_MeTrfase_fam.
DR PANTHER; PTHR11061; RNA M5U METHYLTRANSFERASE; 1.
DR PANTHER; PTHR11061:SF30; TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE; 1.
DR Pfam; PF02475; Met_10; 1.
DR Pfam; PF05958; tRNA_U5-meth_tr; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51687; SAM_MT_RNA_M5U; 1.
DR PROSITE; PS01230; TRMA_1; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01024}; Reference proteome {ECO:0000313|Proteomes:UP000236752};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01024};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01024}.
FT DOMAIN 254..316
FT /note="SAM-dependent methyltransferase TRM5/TYW2-type"
FT /evidence="ECO:0000259|Pfam:PF02475"
FT ACT_SITE 362
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10015"
FT ACT_SITE 362
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 241
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 268
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 288
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 336
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
SQ SEQUENCE 406 AA; 43696 MW; 5F0C0EE3B1A91A73 CRC64;
MEQYKIDRLG HQGDGIAEGP VYVPGALPGE IVQGTLDGSV LRDAKIIEPS SDRVRPPCSH
AKSCGGCQLQ HASDDFVAKW KMEVVERALA AHGITTQMRP ILTSPAQSRR RAAFSAKRTK
KAAIAGFHKK QSDIVIAIPN CQLVHPDVMA ALPLVEELAV VGGSRKGEIS VLVTLTDNGL
DLYVSGGKPI DDALRITLSD LTRKYNIARI SWDDEIALQR EKPILRLGNA PVSPPPGAFL
QATKDGEAAL VAAVREIVGS GKRVADLFAG CGTFALPLAE KAEVLAVEGD KAMTHALEEG
WRQGKNLKKL TPLARDLFRN PLLPDELAKM DALVIDPPRA GAEAQVAQIA KSNVPVIAHV
SCNPTTFARD CGTLIAAGYQ LDWVQTVDQF RWSTHVEVVG CLTKRK
//
