ID A0A1H6AS85_9RHOB Unreviewed; 634 AA.
AC A0A1H6AS85;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Beta-galactosidase {ECO:0000256|ARBA:ARBA00012756, ECO:0000256|PIRNR:PIRNR001084};
DE Short=Beta-gal {ECO:0000256|PIRNR:PIRNR001084};
DE EC=3.2.1.23 {ECO:0000256|ARBA:ARBA00012756, ECO:0000256|PIRNR:PIRNR001084};
GN ORFNames=SAMN04488045_3105 {ECO:0000313|EMBL:SEG51024.1};
OS Thalassococcus halodurans.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Thalassococcus.
OX NCBI_TaxID=373675 {ECO:0000313|EMBL:SEG51024.1, ECO:0000313|Proteomes:UP000236752};
RN [1] {ECO:0000313|EMBL:SEG51024.1, ECO:0000313|Proteomes:UP000236752}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 26915 {ECO:0000313|EMBL:SEG51024.1,
RC ECO:0000313|Proteomes:UP000236752};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001412,
CC ECO:0000256|PIRNR:PIRNR001084};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 42 family.
CC {ECO:0000256|ARBA:ARBA00005940, ECO:0000256|PIRNR:PIRNR001084}.
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DR EMBL; FNUZ01000005; SEG51024.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H6AS85; -.
DR OrthoDB; 9800974at2; -.
DR Proteomes; UP000236752; Unassembled WGS sequence.
DR GO; GO:0009341; C:beta-galactosidase complex; IEA:InterPro.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd03143; A4_beta-galactosidase_middle_domain; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR013738; Beta_galactosidase_Trimer.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR003476; Glyco_hydro_42.
DR InterPro; IPR013529; Glyco_hydro_42_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR36447; BETA-GALACTOSIDASE GANA; 1.
DR PANTHER; PTHR36447:SF2; BETA-GALACTOSIDASE YESZ; 1.
DR Pfam; PF02449; Glyco_hydro_42; 1.
DR Pfam; PF08532; Glyco_hydro_42M; 1.
DR PIRSF; PIRSF001084; B-galactosidase; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|PIRNR:PIRNR001084};
KW Hydrolase {ECO:0000256|PIRNR:PIRNR001084};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR001084-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000236752};
KW Zinc {ECO:0000256|PIRSR:PIRSR001084-3}.
FT DOMAIN 8..391
FT /note="Glycoside hydrolase family 42 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02449"
FT DOMAIN 402..589
FT /note="Beta-galactosidase trimerisation"
FT /evidence="ECO:0000259|Pfam:PF08532"
FT ACT_SITE 144
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001084-1"
FT ACT_SITE 316
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR001084-1"
FT BINDING 105
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001084-2"
FT BINDING 109
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR001084-3"
FT BINDING 143
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001084-2"
FT BINDING 324
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001084-2"
SQ SEQUENCE 634 AA; 71185 MW; 434E179606C7C2FD CRC64;
MKRTLGTCYY PEHWPEDIWE KDAARMVETG LTWVRIGEFA WGKIEPREGE FHWDWLDRAI
DVLGRAGLKV VLGTPTATPP RWVVNKHPDM IAVDVDGKPR KFGSRRHYCF SHEGFSAESR
RITEKVAQRY GKNPYVAAWQ TDNEYGCHDT VISYSDAARL AFRDWLRNAF NDDIDALNTA
WGNVFWSMDY ADFDDIDLPN LTVTEPNPAH ALAFRRFSSD QVVQFNREQV DIIRAHSDAP
ISHNYMGRIT DFDHYKVGRD LEIATWDSYP LGFLEDRVGA DAERQRKYAR QGDPDFQAFH
HDLYRAVGLG RWWVMEQQPG PVNWAPYNPA PLPGMVRLWT WEAFAHGAEA VCYFRWRQAP
FAQEEMHTGM LRPDSADAPA IIEARQVRDE LIDAPMVQPA QAPVALIFDY DADWAWTVQP
HGAGLSYFGL VFEHYRALRR AGLSVDILPP DTRDFSGYAA VFAPGLMHMP DDLKAALNAA
DAQVVLGPRS AARDAHFSIP NPLPPAFPDL DVTVTLVESL RPDSPMTLSG GGAFAGYREE
LSGEAETVMT LTDGRAAVKR AGHVSYVGGW GDDAALERIV AMICQAAGVP VMDLPDGLRT
RATATERFWF NHTDSEITFG GRTIPAAGVL REAS
//