ID A0A1H6B5E2_9ACTN Unreviewed; 434 AA.
AC A0A1H6B5E2;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Precorrin-6Y C5,15-methyltransferase (Decarboxylating) {ECO:0000313|EMBL:SEG55764.1};
GN ORFNames=SAMN04489712_106257 {ECO:0000313|EMBL:SEG55764.1};
OS Thermomonospora echinospora.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Thermomonosporaceae; Thermomonospora.
OX NCBI_TaxID=1992 {ECO:0000313|EMBL:SEG55764.1, ECO:0000313|Proteomes:UP000236723};
RN [1] {ECO:0000313|Proteomes:UP000236723}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43163 {ECO:0000313|Proteomes:UP000236723};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953}.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
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DR EMBL; FNVO01000006; SEG55764.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H6B5E2; -.
DR OrthoDB; 9787825at2; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000236723; Unassembled WGS sequence.
DR GO; GO:0008276; F:protein methyltransferase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd11644; Precorrin-6Y-MT; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR012818; CbiE.
DR InterPro; IPR006365; Cbl_synth_CobL.
DR InterPro; IPR014008; Cbl_synth_MTase_CbiT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR02467; CbiE; 1.
DR NCBIfam; TIGR02469; CbiT; 1.
DR PANTHER; PTHR43182; COBALT-PRECORRIN-6B C(15)-METHYLTRANSFERASE (DECARBOXYLATING); 1.
DR PANTHER; PTHR43182:SF1; COBALT-PRECORRIN-7 C(5)-METHYLTRANSFERASE; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR PIRSF; PIRSF036428; CobL; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE 3: Inferred from homology;
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:SEG55764.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000236723};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SEG55764.1}.
FT DOMAIN 13..192
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT REGION 409..434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 434 AA; 45647 MW; 479FEA8608C9C9D5 CRC64;
MITVVGYDGS PLPALALERL AQASLVVGGA RHLSAVPLPP GARTVVMGDV TAALDEIDKE
LGDRAAPSRN AADEGGVVVL ASGDPGFFGI VRALRERGHR PQVLPALSSV AQAFARVGLP
WDDALVVSAH GRELRRAVNA CRAHPKVAVL TAPGAGPAEL GRALFPQHPR VFVVCEDLGG
PDERVTRCRP AEATTRHWRD PNVVLVLDER RPAEERGWIA GARPGPPSWA LPEDAFEHRN
SVVTKAEVRA FALARLGPRV GDLIWDIGAG SGSVAIECAR FGAAAVAVER DAASCERIRG
NVRAHGVRVA VSRGEVPAVL EHLPDPDAVF VGGGGPDVVR ACASRALRSV VVALASIERV
RPALDALTAE GLTAEAVQLQ ANRLSPLPGD VHRLAATNPV FLVWGERNAG PPPARAARPA
RRPQTLAELP ETDQ
//
