ID   A0A1H6BAY5_9ACTN        Unreviewed;       726 AA.
AC   A0A1H6BAY5;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Putative drug exporter of the RND superfamily {ECO:0000313|EMBL:SEG57800.1};
GN   ORFNames=SAMN05216223_106363 {ECO:0000313|EMBL:SEG57800.1};
OS   Actinacidiphila yanglinensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Actinacidiphila.
OX   NCBI_TaxID=310779 {ECO:0000313|EMBL:SEG57800.1, ECO:0000313|Proteomes:UP000236754};
RN   [1] {ECO:0000313|EMBL:SEG57800.1, ECO:0000313|Proteomes:UP000236754}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 4.2023 {ECO:0000313|EMBL:SEG57800.1,
RC   ECO:0000313|Proteomes:UP000236754};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; FNVU01000006; SEG57800.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H6BAY5; -.
DR   OrthoDB; 7051771at2; -.
DR   Proteomes; UP000236754; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000236754};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        177..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        202..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        235..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        284..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        309..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        353..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        511..530
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        542..565
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        585..606
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        627..648
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        668..690
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          564..682
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
FT   REGION          701..726
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   726 AA;  75227 MW;  6353240062AD1517 CRC64;
     MERLATWVTR HRLTVGLLWL VVTAVGVVLA PSLSGRLQSG NHVSGPGFTA NTAIAAHYGG
     AASDPGVLIL NAPPGRTVDA QPVKQELVRV DATLAKAAPN LRLVSYAANG DAALVGANRA
     GTIVLAYPPN VGDDVGPAQM DQLTAAAKQA APDLSVHGTS YHALEAGNTS GGGNGSVLSE
     LIVGALGALL VLAWVFGSFL ALLPLIMALI SVLTMQIFIY GLTYLVPSSS PINPAVQYIV
     ALLGLGLSID YSLLVVTRWR EERGAGKTND EAVLAAVKRA GHSVWFSGVV ASLGLFALVV
     IPNSMVRGIG ISGLFIPSTA TLVALTLLPA ILSKAGPRLD WPRRASRRNP VSGFWTAWSV
     GVIKHRVLAA VVGLGLLVGL AATATTINIA QPTTQAMASA GSYTDGLHAL ETDGFPSGTL
     TAVPIYVPHA ADAPAVVDSL ATVSSLRGAA LATGTRWSST DGSALVVAVP RTEVGSSHGG
     TALADIRAAA GHGALAGGDG AQKIDETKAT YGSFPLLFAV VALFTFLLLA RGMRSLVLPA
     KAVLLNMLSV AATYGVLVLV FQHGIGMQTL WGTSSYGAID SLVPVLIFGF LFGVSMDYEV
     FILARIREGH DRSRSTREGI IEGVSRTGRL VTSAALILFF ALASLSTAND VTVREIAAGL
     AAGVVLDAVV VRMLLLPALV ALFGEWNWWL PDGARRLLRL EPPAPSRTPQ LEREPAEAGR
     AMEDAG
//