ID A0A1H6C1M2_9ACTN Unreviewed; 319 AA.
AC A0A1H6C1M2;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=5'-3' exonuclease {ECO:0000313|EMBL:SEG66861.1};
GN ORFNames=SAMN04489712_108231 {ECO:0000313|EMBL:SEG66861.1};
OS Thermomonospora echinospora.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Thermomonosporaceae; Thermomonospora.
OX NCBI_TaxID=1992 {ECO:0000313|EMBL:SEG66861.1, ECO:0000313|Proteomes:UP000236723};
RN [1] {ECO:0000313|Proteomes:UP000236723}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43163 {ECO:0000313|Proteomes:UP000236723};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FNVO01000008; SEG66861.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H6C1M2; -.
DR Proteomes; UP000236723; Unassembled WGS sequence.
DR GO; GO:0017108; F:5'-flap endonuclease activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0033567; P:DNA replication, Okazaki fragment processing; IEA:InterPro.
DR CDD; cd09898; H3TH_53EXO; 1.
DR CDD; cd09859; PIN_53EXO; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N.
DR InterPro; IPR002421; 5-3_exonuclease.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR020045; DNA_polI_H3TH.
DR InterPro; IPR038969; FEN.
DR InterPro; IPR008918; HhH2.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR PANTHER; PTHR42646:SF2; DNA-DIRECTED DNA POLYMERASE; 1.
DR PANTHER; PTHR42646; FLAP ENDONUCLEASE XNI; 1.
DR Pfam; PF01367; 5_3_exonuc; 1.
DR Pfam; PF02739; 5_3_exonuc_N; 1.
DR SMART; SM00475; 53EXOc; 1.
DR SMART; SM00279; HhH2; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000313|EMBL:SEG66861.1};
KW Hydrolase {ECO:0000313|EMBL:SEG66861.1};
KW Nuclease {ECO:0000313|EMBL:SEG66861.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000236723}.
FT DOMAIN 12..284
FT /note="5'-3' exonuclease"
FT /evidence="ECO:0000259|SMART:SM00475"
SQ SEQUENCE 319 AA; 33440 MW; 7D749C0DBA112C45 CRC64;
MSPARGTMAS MSALMLLDTP SLYFRAFFGV PESVTAPDGT PVNAVRGLID MIARLVRDRS
PARLVCCMDA DWRPAFRVAA LPSYKAHRVA DDGGDQTPDP LAAQLPVIDA VLDAAGLVRA
GVPGYEADDV IGTLTARHAA AGGAVDIVTG DRDLFQLVDE RGPVQVLYTA RGIRNLQVMG
EKEVAAKYGI PGRAYGDYAT LRGDPSDGLP GVPGVGDKTA AALVTRFGSI AGILDALDAG
ATEGFPAGSR RRLEAARDYL AAAETVVKVV TDIDAPELAA LDDTLPRAPR DPRALAELAE
RWNLGSPVKR LQDALAAVS
//
