ID A0A1H6DMM2_9GAMM Unreviewed; 652 AA.
AC A0A1H6DMM2;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|ARBA:ARBA00021975, ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN ORFNames=SAMN05444390_107199 {ECO:0000313|EMBL:SEG86479.1};
OS Marinobacterium lutimaris.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Oceanospirillaceae; Marinobacterium.
OX NCBI_TaxID=568106 {ECO:0000313|EMBL:SEG86479.1, ECO:0000313|Proteomes:UP000236745};
RN [1] {ECO:0000313|EMBL:SEG86479.1, ECO:0000313|Proteomes:UP000236745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22012 {ECO:0000313|EMBL:SEG86479.1,
RC ECO:0000313|Proteomes:UP000236745};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
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DR EMBL; FNVQ01000007; SEG86479.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H6DMM2; -.
DR OrthoDB; 9763467at2; -.
DR Proteomes; UP000236745; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03482; MutL_Trans_MutL; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}; Reference proteome {ECO:0000313|Proteomes:UP000236745}.
FT DOMAIN 213..333
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 465..608
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 342..415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 652 AA; 71544 MW; 37CF1888AA4D8523 CRC64;
MSRIHLLSPQ LANQIAAGEV VERPASVVKE LLENSLDAGA TKIDVDVEQG GIKLIRLRDN
GGGIEKGDLA LALSRHATSK ILQLEDLEAV ASLGFRGEAL ASISSVARLT LTSRTKDQEA
AWQVRAEGRD MEAVLEPAAH PRGTTVEVRD LFFNTPARRK FMKKDQTEFR HLEEVIKRMA
LSRFDVSFNL QHNGRRVQQL RPVDSEQARE RRLASLLGGS FIEQAVHLDV SAEASGLRLW
GWIGLPTYSR SQADQQYFFV NGRIIRDKVV THAVRQAYSD VLFHGRHPAF VLYLELDPAL
VDVNVHPTKH EVRFRESRLV HDFIFRTLHR VIGDLRPKDA VPAGAGESAG DGAGAPSMAM
QSSPGSVSGG GTFSQGRMPL YQSSGSYQSP GSYQSSGNYQ PGQSPGNYGS YGGAAGSASA
VRDQISAYAD LHTPAAPAQG LQNVGRPGMP MPEDDAEKAP PLGYAIAQLH GVYVLAQNEV
GLVLVDMHAA HERIVYERMK TAWDEDRVRS QPLLVPVSLS VSEREADLAE EQPELFERLG
FRLERMGADT LTVREVPVSL AKADAPQLVR DVLADLVVFG SSRRIEESIN ELLGTMACHG
AVRANRQLSI PEMNALLRDM EATERSGQCN HGRPTWTQLS MHELDKLFLR GQ
//
