ID A0A1H6DT47_9ACTN Unreviewed; 1588 AA.
AC A0A1H6DT47;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=WD40 repeat {ECO:0000313|EMBL:SEG87923.1};
GN ORFNames=SAMN04489712_12137 {ECO:0000313|EMBL:SEG87923.1};
OS Thermomonospora echinospora.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Thermomonosporaceae; Thermomonospora.
OX NCBI_TaxID=1992 {ECO:0000313|EMBL:SEG87923.1, ECO:0000313|Proteomes:UP000236723};
RN [1] {ECO:0000313|Proteomes:UP000236723}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43163 {ECO:0000313|Proteomes:UP000236723};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FNVO01000021; SEG87923.1; -; Genomic_DNA.
DR OrthoDB; 414967at2; -.
DR Proteomes; UP000236723; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00200; WD40; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 5.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR049052; nSTAND1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22847:SF637; WD REPEAT DOMAIN 5; 1.
DR PANTHER; PTHR22847; WD40 REPEAT PROTEIN; 1.
DR Pfam; PF08662; eIF2A; 1.
DR Pfam; PF20703; nSTAND1; 1.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 12.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 8.
DR PROSITE; PS50294; WD_REPEATS_REGION; 5.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000236723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 722..742
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 248..666
FT /note="Novel STAND NTPase 1"
FT /evidence="ECO:0000259|Pfam:PF20703"
FT REPEAT 805..846
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 848..889
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 930..955
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 933..993
FT /note="Translation initiation factor beta propellor-like"
FT /evidence="ECO:0000259|Pfam:PF08662"
FT REPEAT 1018..1048
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1050..1086
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1133..1173
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1266..1307
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1309..1350
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1588 AA; 169117 MW; B7A9D48A2BDFE1EE CRC64;
MSDGSEPEDD ERAHDGQPGE EQDERNRLML AGMRGRLGRW ARSSGSQALR WTPGTLIAVL
AAGAFSPLLT GGALVATGFG VLGAVGGNVL TDVLQSAVQR LRPDASQDEI AEEIQRRIEE
LLAEGGDRAA SLRSDIARVL QGVGSMGELL GEALSDQEEA RQRLLAGLAA LGEEFGEFRF
LLQDVTDALD TLQTSADLHS MQHDQMIDLQ HRQLTETRLV RGDLAALGRG LPGEREPAPA
ARWSGDCPYR GLAAFREIDA ELFHGRAQAT EELVRIAART MATRRDGPHL VVVTGASGVG
KSSLLRAGLL PALAEAAGEL PAEVAHWPRI VTTPTAFGPP LRTLALHLAA LARIGDPDAL
RERLAAEPER AGPLIRQALL AEGLRRQRAG AAGDDLRLVL VVDQFEDLFG PNGPGDAQAR
AFVAALHAAA VSPRAGHGVP PALVVIAVRG DRIDDCARHP VLRQALQESQ FVLGPMEEPD
LRRAIIGQAE AAGLRIENRL VETILAELRS PELAAFKSGT LPLLSQAMLL TWERREGNRL
SDRAYELSGG VRKAVEKSAE EVYAGLTPEE QALAEGALRR LTLIGRDERP VGRRVPLEDL
SGRSLRVLEK FAAKRLVVIG NGGAEPAHQM LLEAWPQLRD WLKADVEEWK LYGRLVQDAE
QWSGSRLDPS FLYRGRQLET IREAERRWPA DPGRFPTLEE RQREFLNASA AAETERLRRR
QALLGAIAAL VVIALVAVVS AVRVGGRADA EHAAGLSRRL AASGARTSDP VVAALLAAAA
WRVAPTDEAR HGLRAVLAGR HRGTLVGHLD GVRAVAFSPD GRTLATGGTD SLVRLWDVAS
HRPIGRPLAG HAGTVTSVAF GPDGRTLTSA GDDRTVQLWD VAAKRRVTAL AVGSAGPAVL
GPGGSTFFAG ERLWDLASRR PVGEPLDTTV GGVAFSPDGR MVATADLEGH VRLWDTAIQR
QIGRTLTGAA GPLTFSPDGA FLLTSTGTAR LRLWEVAGQR TLGDLPGCAS GVPARVTAFD
RDGDTIAVGC GDGSLRLWDV FTRRLLIEPI KGHDAAVTSI SFSPDGTTLA SAGDGEGAVR
LWDVRSPLLA SVSDRDGPVA ADRSGRRLAT GAVGNGDWHV RAWDLTTGRN TALGGHDDWT
RAFAFSPDGG GLAAAADDRV QIWDLASGRI RTTLADVGPV QALAYSADGK SLLVVASEAG
FTVGRWDVTS GRLLRTLAPK VAPSENLESS GHLTLSPDLR LLAMVGNGQT VRLWDLAGGR
FAGGPMAGHT DRIDDVAFSP DGRLIATAGS DRTLRLWDTA TRRPVGQPLT GHTDDVLTVA
FSEDGRTLAS GGRDGTIRLW DTATRSPLGA PFTGPFESVR ALAFLPGRGT LAAVDDTRTL
RLWRVGEPSD LLGAVCATAG RPMTRAEWQR YAPGEEFQTV CDHRPAAPPV FPSAKGFPTP
LPVVTPSASA RAAAPARAAQ FAGRYTLVLD AAATKAAFRP EAPAQTYPLQ QDITNKAALY
RGSRPIDFEA ACTGPDCALR LTGFAGEPPI TLARTRSGTF QGSTGDRTWT VRADTIAADR
VTTFTLTYLI RDRSRVYSGT LEFRGARS
//
