ID A0A1H6E6Q1_9ACTN Unreviewed; 823 AA.
AC A0A1H6E6Q1;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=SAMN04489712_13452 {ECO:0000313|EMBL:SEG92624.1};
OS Thermomonospora echinospora.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Thermomonosporaceae; Thermomonospora.
OX NCBI_TaxID=1992 {ECO:0000313|EMBL:SEG92624.1, ECO:0000313|Proteomes:UP000236723};
RN [1] {ECO:0000313|Proteomes:UP000236723}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43163 {ECO:0000313|Proteomes:UP000236723};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; FNVO01000034; SEG92624.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H6E6Q1; -.
DR Proteomes; UP000236723; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd06225; HAMP; 2.
DR CDD; cd16922; HATPase_EvgS-ArcB-TorS-like; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd17546; REC_hyHK_CKI1_RcsC-like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 1.20.120.1530; -; 2.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR45339; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J; 1.
DR PANTHER; PTHR45339:SF1; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J; 1.
DR Pfam; PF13185; GAF_2; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF18947; HAMP_2; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00304; HAMP; 2.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 1.
DR PROSITE; PS50885; HAMP; 2.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:SEG92624.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000236723};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 20..72
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 112..164
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 416..649
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 700..817
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT REGION 649..673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 330..385
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 651..665
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 750
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 823 AA; 89042 MW; 8DBB92FED6958727 CRC64;
MRGVSGVWKD LTNNVNGMAS NLTYQVRNIA QVTTAVAHGD LTKKIDVDAR GEILELKTTI
NTMVDTLSAF SSEVTRVARE VGSEGRLGGQ AKVEGVYGTW KRLTENVNEL ASNLTTQVRA
IAEVTSAVAS GDLSREITVE AAGEVAELKD NVNLMVATLR ETTHANQEQD WLKSNLARIG
GLLQGHRDMT QMAQLIMSEL TPTASADYGA FYLARPNGDG ETELALIAGY GVRPTPDGTS
FRLGEGLVGQ AALERRMILI DNAPPGYVTI RSGLGQASAT HVIVLPVLFE DQVLGAIELA
SFGGFTATHL AFFDQFAETL GVTINAISAN SRTEALLTES QRLAQELQER SDELQRQQAE
LRRSNAELED KAALLAKQNR AIEIQNFQIE QARRTLEERA EQLALSSRYK SEFLANMSHE
LRTPLNSLLV LAKLLSENPE GNLSAKQVEF ARTIHDSGTD LLQLINDILD LSKVEAGKME
VHPQPLAFTK LVDYVDATFR PMAVDKGLAF GIEVAPDVPG LLYADEQRLQ QVLRNLLSNA
VKFTSEGEVK LTIAPAGNDE EFSAPGLREA PLVIGFEVSD TGIGISEDKL QVIFEAFQQA
DGTTSRRYGG TGLGLSISRN IAHLLGGEIH ARSQLGRGSR FTLYLPAQYQ GAGSPPPPAE
VEPPVSSGRP APEAAAGPAL AEFLEEPPAD HLDAVLSGRK VLIVDDDVRN VFALTSVLEG
YGMDVLYAED GQAGIDLLQR NPDVALVLMD VMMPGLDGYA TTEAIRGMPQ FTDLPIIVIT
AKVMKGDREK SLASGASDYV PKPVDVDHLL DLMRTWLQRA TVR
//
