ID   A0A1H6EQD8_9ACTN        Unreviewed;      1216 AA.
AC   A0A1H6EQD8;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 34.
DE   SubName: Full=Amino acid adenylation domain-containing protein {ECO:0000313|EMBL:SEH00067.1};
GN   ORFNames=SAMN05444920_11546 {ECO:0000313|EMBL:SEH00067.1};
OS   Nonomuraea solani.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Streptosporangiaceae; Nonomuraea.
OX   NCBI_TaxID=1144553 {ECO:0000313|EMBL:SEH00067.1, ECO:0000313|Proteomes:UP000236732};
RN   [1] {ECO:0000313|EMBL:SEH00067.1, ECO:0000313|Proteomes:UP000236732}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 4.7037 {ECO:0000313|EMBL:SEH00067.1,
RC   ECO:0000313|Proteomes:UP000236732};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR   EMBL; FNVT01000015; SEH00067.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H6EQD8; -.
DR   OrthoDB; 3671989at2; -.
DR   Proteomes; UP000236732; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR   GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   CDD; cd12117; A_NRPS_Srf_like; 1.
DR   CDD; cd19543; DCL_NRPS; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR001031; Thioesterase.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR   PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   Pfam; PF00668; Condensation; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   Pfam; PF00975; Thioesterase; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   SUPFAM; SSF47336; ACP-like; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR   PROSITE; PS00455; AMP_BINDING; 1.
DR   PROSITE; PS50075; CARRIER; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000236732}.
FT   DOMAIN          878..952
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   REGION          676..695
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1216 AA;  130698 MW;  F024065BBD775DD7 CRC64;
     MSGRLADVLP LSPAQEGLLF HALYGGDDAY VVQARFAIDG QADPARLRAA LESLLDRHPN
     LRACFRHKGL DRPVQLVPHR VRLPWTEVDP PSEAELERML EADRLRPFDV TRPPLVRATL
     VGRRELVLTM HHLLVDGWSM PILAGELATL YAGDGVLPPA PAYKDYLTWL HAQDGERALA
     EWRAALADLP GPTLVRPGAV AASLRQEVVE LELTRERSEA VRRRAREAGV TLNTLVQAAW
     GQVLGRMTGR DDVVFGAVVS GRPPEVPGVE SMAGLFINAL PVRVRTGEPL SRLQDEQSRL
     TPYHHVRLAD VQRGTGELFD TLLAFENYPR DGLSSPGIRL TDVHDATHYP LTVTVVAGER
     LWLRLGHRAD LFTRAEAEAV AERLVTALES DELPPAESHR LLVTWNDTAR PETAGSVPER
     FAAQAARTPD AVAVEHGGHA LTYAELDARS DRVAARLAIE PETPVAVLME RSPDLVVALL
     AVLKAGGCYV PLDPGQPPAR LEWLLADSGA RVVLTSLDES GGPAFEGPPL RRDAAAYVMY
     TSGSTGTPKG VVVTHANILE LAADRRFAGH RRVLLHSPHT FDAATYELWV PLLNGGTVVV
     APPGPLRPDT IAGARLSAVW LTAELFRALT DLAPDALATV PEVWAGGDVL APDTVRRAAR
     HGVQVVNGYG PTETTTFATS HRVGPEPGTG SVPIGRPLDN TRVYVLDPRL RPAPAGTVGE
     LYVAGTGLAR GYLGRPGPTA ERFVADPFGG PGERMYRTGD LARWTFDGEL EFAGRADGQV
     KIRGYRIEPG EVEAALESCP DVRRAVVITA SLGGAVRLVA YVVTDAIERV REQAAARLPQ
     HLLPARYIPL DRLPLTAHGK VDRAALPAPE APSVTVTEPA TPREKELCGL FAQVLGGEAG
     ADTDFFDAGG DSLLAMRLTA AIEAEIGIRT SIAALFEAPT PAKLAVRLDR TAPELDLSPL
     LTLRAEGDRA PLFCVHPGRG IGWSYTALLP HLTPGRPVYA LQSPVLQAGV HTLPGGMREL
     AEEYLARVRA VRPDGPYLLL GHSFGGLLAY EMAARLREDG QEVGLVASLD AVPWPPGFEA
     EPAGLEQEAL TILLRTRTLH PYAQPGPLER ARVFAAVRDS EGPLSGMDDA GLSAVADTVA
     GHLRLAVTYR PPPYDGTVLL FSATAQPGGL GSAVKTERWS PARVRVHELD CGHSDLLRPG
     SAAEIAGVLE PILREW
//