ID A0A1H6ETR1_9ACTN Unreviewed; 1182 AA.
AC A0A1H6ETR1;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=SAMN05444920_119122 {ECO:0000313|EMBL:SEH01192.1};
OS Nonomuraea solani.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Streptosporangiaceae; Nonomuraea.
OX NCBI_TaxID=1144553 {ECO:0000313|EMBL:SEH01192.1, ECO:0000313|Proteomes:UP000236732};
RN [1] {ECO:0000313|EMBL:SEH01192.1, ECO:0000313|Proteomes:UP000236732}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.7037 {ECO:0000313|EMBL:SEH01192.1,
RC ECO:0000313|Proteomes:UP000236732};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; FNVT01000019; SEH01192.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H6ETR1; -.
DR Proteomes; UP000236732; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd12113; PHP_PolIIIA_DnaE3; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000236732};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 7..74
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1182 AA; 129168 MW; BCE07F1F6D2AD0D3 CRC64;
MFVASFVHLH VHTEYSMLDG AAKVGLLMKE VSRQGMPAVA MSDHGNVHGA YEFHHAARKA
GVKPIIGIES YVAPASRRHR QPVFYSDNLA LRKSNDDTGE GGDVSGRGLY THMTMWAADA
RGLRNLFRLQ SRAWLEGHVQ KYPRMDDELL AEHGQGIIAT TGCPSGEVQT RLRLGQYDRA
VEAAARYRDL FGPGNYFLEL MDHGLAIERR VREDLLRLGR DLGLPPLATN DSHYVTEDQA
RAHDVLLCVG TGKRLADAER FRFSGSGYYV KSAGEMRALW DGEVPGACDN TLLIAERVGD
YDEVFAHRDL TPRFPVPEGE SESSWLRAET LEGARDRYGA RPPQEVLDRI DYELSVIDMM
GFPGYFLVVA DICRYAREHG IGLGPGRGSA TGSIVAYCTG ITQLDPIEHK LIFERFLNPE
RISMPDVDLD FDDRRRDEMI DYVTRKYGED RVCQIVTFGT IKAKAAIKDS CRVLGLPYAL
GDRITKAFPA AVGGKEIPLA AIHDAGHPRH GEAAELRQLY EQDPDVKRVV DTAAGIEGLT
RGTGVHAAGV ILSSEPLTDV IPLARPKADG PIVTGFPFTQ AEEMGLLKMD FLGLRNLTVI
GDAVAGVRAN KGLDIDIREV PLDDATTYEL LARGDTLGVF QLDSGGMRVL LRLMQPTTFT
DIAAVNALYR PGPMEMNAHT NYALRKTGKQ PVEPIHPELA DALEPILGDT YHLVVFQEQV
MAIAQRLAGY SLGAADMLRR AMGKKKKEVL DAEWDRFSAG MRERGFSGEA IKAVWDVLVP
FSGYGFNKSH TAGYGLVSYW TAYLKANHPC EYLAALLTSV GDDKDKMAVY LADCRRLGIK
VLPPDVNASL LNFAAVGTDI RFGLGAVRNV GANVVDAIAT TREARGPYTD FNDFLAKVPS
VVCNKRVIES LAKSGAFDSL GHHRKALVAV HEQAVDGVID LKRNAAHGQD SLFGEPSRSG
AFSVAIPEGE WDQATLLAFE REMLGLYVSS HPLDGAEHVL NAHRDTTIAD LLTSGRQDGV
TRISGIVSGV QRKVTKQGNP WAIVTLEDHD GAVECLIFPK TYSLYGEALA QDQVISVRGR
INVRDETVSV YGEELTPLNV AQAGTEPPVV ISIHETQLSA RLVREFRHIL TTHPGRAPVH
VRLLRNGAAG VLLDLPPFQV TPEPAFYGDV KALLGAGAIG GA
//