GenomeNet

Database: UniProt
Entry: A0A1H6ETR1_9ACTN
LinkDB: A0A1H6ETR1_9ACTN
Original site: A0A1H6ETR1_9ACTN 
ID   A0A1H6ETR1_9ACTN        Unreviewed;      1182 AA.
AC   A0A1H6ETR1;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN   ORFNames=SAMN05444920_119122 {ECO:0000313|EMBL:SEH01192.1};
OS   Nonomuraea solani.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Streptosporangiaceae; Nonomuraea.
OX   NCBI_TaxID=1144553 {ECO:0000313|EMBL:SEH01192.1, ECO:0000313|Proteomes:UP000236732};
RN   [1] {ECO:0000313|EMBL:SEH01192.1, ECO:0000313|Proteomes:UP000236732}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 4.7037 {ECO:0000313|EMBL:SEH01192.1,
RC   ECO:0000313|Proteomes:UP000236732};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FNVT01000019; SEH01192.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H6ETR1; -.
DR   Proteomes; UP000236732; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd04485; DnaE_OBF; 1.
DR   CDD; cd12113; PHP_PolIIIA_DnaE3; 1.
DR   Gene3D; 1.10.150.870; -; 1.
DR   Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR004805; DnaE2/DnaE/PolC.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR004365; NA-bd_OB_tRNA.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   NCBIfam; TIGR00594; polc; 1.
DR   PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   Pfam; PF01336; tRNA_anti-codon; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF89550; PHP domain-like; 1.
PE   4: Predicted;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Reference proteome {ECO:0000313|Proteomes:UP000236732};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          7..74
FT                   /note="Polymerase/histidinol phosphatase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00481"
SQ   SEQUENCE   1182 AA;  129168 MW;  BCE07F1F6D2AD0D3 CRC64;
     MFVASFVHLH VHTEYSMLDG AAKVGLLMKE VSRQGMPAVA MSDHGNVHGA YEFHHAARKA
     GVKPIIGIES YVAPASRRHR QPVFYSDNLA LRKSNDDTGE GGDVSGRGLY THMTMWAADA
     RGLRNLFRLQ SRAWLEGHVQ KYPRMDDELL AEHGQGIIAT TGCPSGEVQT RLRLGQYDRA
     VEAAARYRDL FGPGNYFLEL MDHGLAIERR VREDLLRLGR DLGLPPLATN DSHYVTEDQA
     RAHDVLLCVG TGKRLADAER FRFSGSGYYV KSAGEMRALW DGEVPGACDN TLLIAERVGD
     YDEVFAHRDL TPRFPVPEGE SESSWLRAET LEGARDRYGA RPPQEVLDRI DYELSVIDMM
     GFPGYFLVVA DICRYAREHG IGLGPGRGSA TGSIVAYCTG ITQLDPIEHK LIFERFLNPE
     RISMPDVDLD FDDRRRDEMI DYVTRKYGED RVCQIVTFGT IKAKAAIKDS CRVLGLPYAL
     GDRITKAFPA AVGGKEIPLA AIHDAGHPRH GEAAELRQLY EQDPDVKRVV DTAAGIEGLT
     RGTGVHAAGV ILSSEPLTDV IPLARPKADG PIVTGFPFTQ AEEMGLLKMD FLGLRNLTVI
     GDAVAGVRAN KGLDIDIREV PLDDATTYEL LARGDTLGVF QLDSGGMRVL LRLMQPTTFT
     DIAAVNALYR PGPMEMNAHT NYALRKTGKQ PVEPIHPELA DALEPILGDT YHLVVFQEQV
     MAIAQRLAGY SLGAADMLRR AMGKKKKEVL DAEWDRFSAG MRERGFSGEA IKAVWDVLVP
     FSGYGFNKSH TAGYGLVSYW TAYLKANHPC EYLAALLTSV GDDKDKMAVY LADCRRLGIK
     VLPPDVNASL LNFAAVGTDI RFGLGAVRNV GANVVDAIAT TREARGPYTD FNDFLAKVPS
     VVCNKRVIES LAKSGAFDSL GHHRKALVAV HEQAVDGVID LKRNAAHGQD SLFGEPSRSG
     AFSVAIPEGE WDQATLLAFE REMLGLYVSS HPLDGAEHVL NAHRDTTIAD LLTSGRQDGV
     TRISGIVSGV QRKVTKQGNP WAIVTLEDHD GAVECLIFPK TYSLYGEALA QDQVISVRGR
     INVRDETVSV YGEELTPLNV AQAGTEPPVV ISIHETQLSA RLVREFRHIL TTHPGRAPVH
     VRLLRNGAAG VLLDLPPFQV TPEPAFYGDV KALLGAGAIG GA
//
DBGET integrated database retrieval system