ID A0A1H6F703_9GAMM Unreviewed; 362 AA.
AC A0A1H6F703;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=GDP-mannose 4,6-dehydratase {ECO:0000256|ARBA:ARBA00011989, ECO:0000256|HAMAP-Rule:MF_00955};
DE EC=4.2.1.47 {ECO:0000256|ARBA:ARBA00011989, ECO:0000256|HAMAP-Rule:MF_00955};
DE AltName: Full=GDP-D-mannose dehydratase {ECO:0000256|HAMAP-Rule:MF_00955};
GN Name=gmd_1 {ECO:0000313|EMBL:SEH04804.1};
GN Synonyms=gmd {ECO:0000256|HAMAP-Rule:MF_00955};
GN ORFNames=MBHS_00656 {ECO:0000313|EMBL:SEH04804.1};
OS Candidatus Venteria ishoeyi.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Thiotrichales;
OC Thiotrichaceae; Venteria.
OX NCBI_TaxID=1899563 {ECO:0000313|EMBL:SEH04804.1, ECO:0000313|Proteomes:UP000236724};
RN [1] {ECO:0000313|EMBL:SEH04804.1, ECO:0000313|Proteomes:UP000236724}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MBHS1 {ECO:0000313|EMBL:SEH04804.1};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-
CC deoxy-D-mannose. {ECO:0000256|HAMAP-Rule:MF_00955}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O;
CC Xref=Rhea:RHEA:23820, ChEBI:CHEBI:15377, ChEBI:CHEBI:57527,
CC ChEBI:CHEBI:57964; EC=4.2.1.47; Evidence={ECO:0000256|HAMAP-
CC Rule:MF_00955};
CC -!- COFACTOR:
CC Name=NADP(+); Xref=ChEBI:CHEBI:58349;
CC Evidence={ECO:0000256|ARBA:ARBA00001937,
CC ECO:0000256|HAMAP-Rule:MF_00955};
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. GDP-mannose 4,6-dehydratase subfamily.
CC {ECO:0000256|ARBA:ARBA00009263, ECO:0000256|HAMAP-Rule:MF_00955}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|HAMAP-Rule:MF_00955}.
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DR EMBL; FMSV02000119; SEH04804.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H6F703; -.
DR OrthoDB; 9779041at2; -.
DR Proteomes; UP000236724; Unassembled WGS sequence.
DR GO; GO:0008446; F:GDP-mannose 4,6-dehydratase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0070401; F:NADP+ binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019673; P:GDP-mannose metabolic process; IEA:InterPro.
DR CDD; cd05260; GDP_MD_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR HAMAP; MF_00955; GDP_Man_dehydratase; 1.
DR InterPro; IPR006368; GDP_Man_deHydtase.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR NCBIfam; TIGR01472; gmd; 1.
DR PANTHER; PTHR43715:SF1; GDP-MANNOSE 4,6 DEHYDRATASE; 1.
DR PANTHER; PTHR43715; GDP-MANNOSE 4,6-DEHYDRATASE; 1.
DR Pfam; PF16363; GDP_Man_Dehyd; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|HAMAP-Rule:MF_00955, ECO:0000313|EMBL:SEH04804.1};
KW NADP {ECO:0000256|HAMAP-Rule:MF_00955};
KW Reference proteome {ECO:0000313|Proteomes:UP000236724}.
FT DOMAIN 6..336
FT /note="NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF16363"
SQ SEQUENCE 362 AA; 41400 MW; 234DC9C253E7DDAE CRC64;
MTKRALITGI TGQDGAYLAE FLIKKAYEVH GIKRRTSLFN TDRIDHLYQD PHEQNRDLIL
HHGDMTDSSS LLRIIQQVQP DEIYNLAAQS HVAVSFEEPE YTANADAIGT LRLLEAIRIL
GLEKKTRFYQ ASTSELFGKV QETPQTEKTP FYPRSPYAAA KLYSYWIVVN YREAYGMYAC
NGILFNHESP IRGETFVTRK ITRALARIKL GLQDCLYLGN LDAKRDWGHA KDYVEMQWLM
LQQDKPDDFV IASGEQHSVR EFVSLAAQEI GIVVTWEGQG IDEKGYDKKT GKQIVAVDQR
YFRPTEVETL LGDPSKAKQQ LGWTPKIAFM DLVKEMAATD LKDAERDALI KKEGHKVFNY
HE
//
