ID A0A1H6FKM0_THEAL Unreviewed; 359 AA.
AC A0A1H6FKM0;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=RNA polymerase sigma factor {ECO:0000256|RuleBase:RU362124};
GN ORFNames=SAMN02745716_0232 {ECO:0000313|EMBL:SEH10383.1};
OS Thermoleophilum album.
OC Bacteria; Actinomycetota; Thermoleophilia; Thermoleophilales;
OC Thermoleophilaceae; Thermoleophilum.
OX NCBI_TaxID=29539 {ECO:0000313|EMBL:SEH10383.1, ECO:0000313|Proteomes:UP000222056};
RN [1] {ECO:0000313|Proteomes:UP000222056}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35263 {ECO:0000313|Proteomes:UP000222056};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Sigma factors are initiation factors that promote the
CC attachment of RNA polymerase to specific initiation sites and are then
CC released. {ECO:0000256|RuleBase:RU362124}.
CC -!- SIMILARITY: Belongs to the sigma-70 factor family.
CC {ECO:0000256|RuleBase:RU362124}.
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DR EMBL; FNWJ01000001; SEH10383.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H6FKM0; -.
DR STRING; 29539.SAMN02745716_0232; -.
DR OrthoDB; 9804285at2; -.
DR Proteomes; UP000222056; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0016987; F:sigma factor activity; IEA:UniProtKB-KW.
DR GO; GO:0006352; P:DNA-templated transcription initiation; IEA:InterPro.
DR CDD; cd06171; Sigma70_r4; 1.
DR Gene3D; 1.10.601.10; RNA Polymerase Primary Sigma Factor; 2.
DR Gene3D; 1.10.220.120; Sigma-70 factor, region 1.1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR014284; RNA_pol_sigma-70_dom.
DR InterPro; IPR000943; RNA_pol_sigma70.
DR InterPro; IPR009042; RNA_pol_sigma70_r1_2.
DR InterPro; IPR007627; RNA_pol_sigma70_r2.
DR InterPro; IPR007624; RNA_pol_sigma70_r3.
DR InterPro; IPR007630; RNA_pol_sigma70_r4.
DR InterPro; IPR007127; RNA_pol_sigma_70_r1_1.
DR InterPro; IPR042189; RNA_pol_sigma_70_r1_1_sf.
DR InterPro; IPR013325; RNA_pol_sigma_r2.
DR InterPro; IPR013324; RNA_pol_sigma_r3/r4-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR02937; sigma70-ECF; 1.
DR PANTHER; PTHR30603; RNA POLYMERASE SIGMA FACTOR RPO; 1.
DR PANTHER; PTHR30603:SF47; RNA POLYMERASE SIGMA FACTOR SIGF, CHLOROPLASTIC; 1.
DR Pfam; PF03979; Sigma70_r1_1; 1.
DR Pfam; PF00140; Sigma70_r1_2; 1.
DR Pfam; PF04542; Sigma70_r2; 1.
DR Pfam; PF04539; Sigma70_r3; 1.
DR Pfam; PF04545; Sigma70_r4; 1.
DR PRINTS; PR00046; SIGMA70FCT.
DR SUPFAM; SSF88946; Sigma2 domain of RNA polymerase sigma factors; 1.
DR SUPFAM; SSF88659; Sigma3 and sigma4 domains of RNA polymerase sigma factors; 2.
DR PROSITE; PS00715; SIGMA70_1; 1.
DR PROSITE; PS00716; SIGMA70_2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU362124};
KW Reference proteome {ECO:0000313|Proteomes:UP000222056};
KW Sigma factor {ECO:0000256|ARBA:ARBA00023082,
KW ECO:0000256|RuleBase:RU362124};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU362124};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU362124}.
FT DOMAIN 151..164
FT /note="RNA polymerase sigma-70"
FT /evidence="ECO:0000259|PROSITE:PS00715"
FT DOMAIN 320..346
FT /note="RNA polymerase sigma-70"
FT /evidence="ECO:0000259|PROSITE:PS00716"
SQ SEQUENCE 359 AA; 40958 MW; 868B5544C7117062 CRC64;
MSLPELQELE EVKLLLAKGQ QTGVLTYSEV AEALAEVELD ESDVEELHAF FERCEIELVE
DVAAPEEQVA DLKRRKKAVL DLRPDMTTDS LQLFLKDIGK VPLLTAQQEV ELAKRIERGD
LDAKQKMVES NLRLVVSIAK NYRNQGLPFL DLIQEGTLGL VRAAEKFDYR KGFKFSTYAT
WWIRQAIARA LADKARTIRI PVHVVEKLNK IGRAERKLVT ELGREPTIEE IAEHTGIDPE
EVESIKRSAQ APISLEKPVG DEEESEFGQF IADEKAESPY ERAVDTLTKE TLRQALENLS
YRERRVLELR YGLGGEHPRT LDEVGRTFNV TRERVRQIEN QSLKKLQSLA EAQRLREVA
//
